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Genetic testing in hereditary breast and ovarian cancer using massive parallel …

Ruiz(Anna),Llort(Gemma),Yagüe(Carmen),Baena(… Biomed Res Int 2015-05-11

...BRCA1 and BRCA2 mutations using massive parallel sequencing in a 454 GS Junior bench top sequencer. Our approach was fir...

BRCA-associated ovarian cancer: from molecular genetics to risk management.

Girolimetti(Giulia),Perrone(Anna Myriam),San… Biomed Res Int 2015-05-11

...BRCA1 and BRCA2 genes. The presence of a BRCA mutation in OC patients has been suggested as a prognostic and predictive ...

A preliminary Quality Control (QC) for next generation sequencing (NGS) library…

Concolino(Paola),Costella(Alessandra),Minucc… Clin Chim Acta 2015-05-12

...BRCA1/2 genes and, to date, many studies report the effectiveness of these technologies. Here we show that Gene Scan (GS...

Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (…

Vassilopoulos(Athanassios),Xiao(Cuiying),Chi… J Biol Chem 2015-01-22

...Brca1-associated tumors, we found that breast cancer stem cells (CSCs) exhibit an intrinsic ability to metastasize and a...

MicroRNAs discriminate familial from sporadic non-BRCA1/2 breast carcinoma aris…

Bastos(Elen Pereira),Brentani(Helena),Pasini… PLoS One 2015-03-30

...BRCA1/2 mutations could not explain the majority of cases arising in these patients. MicroRNAs (miRs) have been implicat...

The expression of four genes as a prognostic classifier for stage I lung adenoc…

Okayama(Hirokazu),Schetter(Aaron J),Ishigame… Cancer Epidemiol Biomarkers P… 2015-08-11

...BRCA1, HIF1A, DLC1, and XPO1 that identified stage I lung adenocarcinoma patients with a high risk of relapse. That stud...

BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the ce…

Davis(Anthony J),Chi(Linfeng),So(Sairei),Lee… Nucleic Acids Res 2015-01-15

...BRCA1. BRCA1 interacts with DNA-PKcs in a cell cycle-regulated manner and this interaction is mediated by the tandem BRC...

Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian.

Mersch(Jacqueline),Jackson(Michelle A),Park(… Cancer 2015-03-09

...BRCA1 mutation did not have a significant increase in cancers other than breast and ovarian cancer; however, a trend in ...

Clinicopathologic characteristics of breast cancer in BRCA-carriers and non-car…

Bayraktar(Soley),Amendola(Laura),Gutierrez-B… Breast 2015-08-24

...BRCA1 and BRCA2 mutations, respectively. BRCA1-carriers had a higher likelihood of a positive family history (FH) of bre...

Combination cediranib and olaparib versus olaparib alone for women with recurre…

Liu(Joyce F),Barry(William T),Birrer(Michael… Lancet Oncol 2015-01-27

...BRCA1/2 mutations from nine participating US academic medical centres. We randomly allocated participants (1:1) accordin...

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