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BRCA1 haploinsufficiency for replication stress suppression in primary cells.

Pathania(Shailja),Bade(Sangeeta),Le Guillou(… Nat Commun 2015-12-08

...BRCA1 in the heterozygous state, we established a collection of primary human BRCA1(+/+) and BRCA1(mut/+) mammary epithe...

BRCA1, a 'complex' protein involved in the maintenance of genomic stability.

Savage(Kienan I),Harkin(D Paul) FEBS J 2015-04-15

...BRCA1 mutations often result in defective DNA repair, genomic instability and sensitivity to DNA damaging agents. BRCA1 ...

Combined microRNA and ER expression: a new classifier for familial and sporadic…

Danza(Katia),De Summa(Simona),Pilato(Brunell… J Transl Med 2015-07-15

...BRCA1 tumors and sporadic triple negative (TN) breast tumors share similarities regarding clinical outcomes and some his...

Randomized controlled trial of a telephone-based peer-support program for women…

White(Victoria M),Young(Mary-Anne),Farrelly(… J Clin Oncol 2015-02-23

...BRCA1 or BRCA2 gene mutation. The intervention involved trained peer volunteers contacting women multiple times over a 4...

The molecular significance of methylated BRCA1 promoter in white blood cells of…

Al-Moghrabi(Nisreen),Nofel(Asmaa),Al-Yousef(… BMC Cancer 2015-07-09

...BRCA1 methylation reflects an elevated risk for developing breast cancer (BC), WBC that harbor methylated BRCA1 in both ...

Inherited predisposition to breast cancer among African American women.

Churpek(Jane E),Walsh(Tom),Zheng(Yonglan),Mo… Breast Cancer Res Treat 2015-09-28

...BRCA1 and BRCA2 genes and 20 % (13/65) carried mutations in PALB2, CHEK2, BARD1, ATM, PTEN, or TP53. The mutational alle...

Hormone responsive breast cancer and BRCA1 mutation: mechanism, regulation and …

Zghair(Abdulrazzaq N),Sharma(Rohit),Sharma(A… Curr Pharm Biotechnol 2015-08-31

...BRCA1 is the predominant marker gene responsible for estrogen regulation. However increased exposure to estrogen is not ...

Clinical application of micronucleus test: a case-control study on the predicti…

Bolognesi(Claudia),Bruzzi(Paolo),Gismondi(Vi… PLoS One 2015-07-13

...BRCA1/2 genes were associated with an increased micronuclei frequency. Our results do not support a significant role of ...

Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkena…

Manchanda(Ranjit),Loggenberg(Kelly),Sanderso… J Natl Cancer Inst 2015-02-20

...BRCA1/2 gene-mutation testing in the Ashkenazi Jewish (AJ) population, we compared testing all participants in the popul...

Cost-effectiveness of population screening for BRCA mutations in Ashkenazi jewi…

Manchanda(Ranjit),Legood(Rosa),Burnell(Matth… J Natl Cancer Inst 2015-02-20

...BRCA1/2 mutations detects the high proportion of carriers not identified by cancer family history (FH)-based testing. We...

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