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Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRC…

Peterlongo(Paolo),Chang-Claude(Jenny),Moysic… Cancer Epidemiol Biomarkers P… 2015-09-18

BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The inco...

miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and…

Tang(Hailin),Liu(Peng),Yang(Lu),Xie(Xinhua),… Mol Cancer Ther 2015-08-11

...BRCA1 at the mRNA and protein levels in TNBC. Our data suggest that miR-185 functions as a tumor suppressor in TNBC deve...

A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer.

Li(Da),Bi(Fang-Fang),Chen(Na-Na),Cao(Ji-Min)… Sci Rep 2015-11-06

...BRCA1 and SIRT1 is poorly understood. Here, we showed that: (i) BRCA1 inactivation events (mutation, promoter methylatio...

Novel nonsense mutation of BRCA2 gene in a Moroccan man with familial breast ca…

Guaoua(Soukaina),Ratbi(Ilham),Lyahyai(Jaber)… Afr Health Sci 2015-09-18

...BRCA1 and BRCA2, transmitted as an autosomal dominant form. Male breast cancer is rare and is mainly due to BRCA2 than B...

A comprehensive laboratory-based program for classification of variants of unce…

Eggington(J M),Bowles(K R),Moyes(K),Manley(S… Clin Genet 2015-05-12

...BRCA1/2 genes as a model. Our VCP has lowered the percentage of tests in which one or more BRCA1/2 variants of uncertain...

Lack of association of BRCA1 and BRCA2 variants with breast cancer in an ethnic…

Hasan(Tarique Noorul),Shafi(Gowhar),Syed(Nav… Asian Pac J Cancer Prev 2015-01-21

...BRCA1) and breast cancer associated gene 2 (BRCA2) and the risk of breast cancer. TaqMan based Real Time Polymerase chai...

BRCA1/2 mutations and FMR1 alleles are randomly distributed: a case control stu…

Dagan(Efrat),Cohen(Yoram),Mory(Adi),Adir(Var… Eur J Hum Genet 2015-01-20

...BRCA1/2 mutation carriers, we could not confirm the reported association between FMR1 low genotypes and BRCA1/2 mutation...

A critical role of CD29 and CD49f in mediating metastasis for cancer-initiating…

Vassilopoulos(A),Chisholm(C),Lahusen(T),Zhen… Oncogene 2015-04-28

...Brca1-mutant mouse model. Our data indicated that CSCs, which are enriched in CD24(+)CD29(+)/CD49f(+) cell population, d...

Analysis of induced pluripotent stem cells from a BRCA1 mutant family.

Soyombo(Abigail A),Wu(Yipin),Kolski(Lauren),… Stem Cell Reports 2015-10-23

...BRCA1 5382insC mutant family. All BRCA1 5382insC heterozygous fibroblasts, iPSCs, and teratomas maintained equivalent ex...

Refining the role of BRCA1 in combating oxidative stress.

Marks(Jeffrey R) Breast Cancer Res 2015-05-18

...BRCA1 regulates this pathway. The relative contribution of this activity in BRCA1-associated tumorigenesis and DNA damag...

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