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Characterization of LGALS3 (galectin-3) as a player in DNA damage response.

Carvalho(Renato S),Fernandes(Vanessa C),Nepo… Cancer Biol Ther 2015-02-13

...BRCA1, both involved in HR pathway. In this report we characterized GAL3/BARD1 protein interaction and evaluated the rol...

Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migrat…

Gao(Ran),Singh(Rumani),Kaul(Zeenia),Kaul(Sun… J Gerontol A Biol Sci Med Sci 2015-07-20

...BRCA1, TIN2, MRE11A, and KPNA2) of the nine genes located on chromosome regions identified as the gain of locus in more ...

Enhanced non-homologous end joining contributes toward synthetic lethality of p…

Somyajit(Kumar),Mishra(Anup),Jameei(Aida),Na… Carcinogenesis 2015-03-17

...BRCA1 and BRCA2. The RAD51 paralog RAD51C has been identified as a breast and ovarian cancer susceptibility gene. The pa...

Wild-type genotypes of BRCA1 gene SNPs combined with micro-RNA over-expression …

Medimegh(Imen),Troudi(Wafa),Stambouli(Nejla)… Med Oncol 2015-10-19

...BRCA1 gene are not the unique factor that could inactivate BRCA1 protein which leads to familial breast cancer onset wit...

Can multiple SNP testing in BRCA2 and BRCA1 female carriers be used to improve …

Prosperi(Mattia C F),Ingham(Sarah L),Howell(… BMC Med Inform Decis Mak 2015-04-17

...BRCA1/2 mutation carriers. Our aim was to determine whether validated susceptibility SNP scores improve the predictive a...

Double-strand break repair-adox: Restoration of suppressed double-strand break …

Terasawa(Masahiro),Shinohara(Akira),Shinohar… Cancer Sci 2015-02-17

...BRCA1 localization to DSB sites, which is important to promote non-homologous end joining or homologous recombination, r...

Exome sequencing identifies FANCM as a susceptibility gene for triple-negative …

Kiiski(Johanna I),Pelttari(Liisa M),Khan(Sof… Proc Natl Acad Sci U S A 2015-04-24

...BRCA1, BRCA2, PALB2, CHEK2, and other genes involved in DNA repair. However, most families severely affected by breast c...

Small-molecule "BRCA1-mimetics" are antagonists of estrogen receptor-α.

Ma(Yongxian),Tomita(York),Preet(Anju),Clarke… Mol Endocrinol 2015-09-01

...BRCA1-ER-α complex (with ER-α liganded to 17β-estradiol), we identified a candidate group of small-molecule compounds pr...

The performance of BRCA1 immunohistochemistry for detecting germline, somatic, …

Meisel(J L),Hyman(D M),Garg(K),Zhou(Q),Dao(F… Ann Oncol 2015-07-07

...BRCA1 IHC with germline BRCA1 mutations and BRCA1 loss through any mechanism. Kaplan-Meier methods were used to estimate...

The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation respo…

Brett-Morris(Adina),Wright(Bradley M),Seo(Yu… Cancer Res 2015-03-04

...BRCA1 expression, explaining decreased HR capacity. Our findings suggest that the biologic significance of elevated SAT1...

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