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The functional BRCA1 rs799917 genetic polymorphism is associated with gastric c…

Wang(Kun),Xu(Longfang),Pan(Lin),Xu(Kesen),Li… Tumour Biol 2015-05-11

...BRCA1 or significant BRCA1 down-regulation via hypermethylation of its promoter in human gastric cancer specimens, highl...

BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a …

Burdak-Rothkamm(Susanne),Rothkamm(Kai),McCle… Cancer Lett 2015-03-03

...BRCA1 and FANCD2 foci formed in T98G bystander cells. Using ATR mutant F02-98 hTERT and ATM deficient GM05849 fibroblast...

Metastatic patterns of breast cancer subtypes: what radiologists should know in…

Chikarmane(S A),Tirumani(S H),Howard(S A),Ja… Clin Radiol 2015-02-09

...BRCA1 mutations carriers, and carry the worst overall prognosis, with high incidence of CNS metastases, especially durin...

Ultraselective electrochemiluminescence biosensor based on locked nucleic acid …

Zhang(Xi),Zhang(Jing),Wu(Dongzhi),Liu(Zhijin… Analyst 2015-10-22

...BRCA1 gene related to breast cancer. More than 65-fold signal difference can be observed with perfectly matched target s...

Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD…

Tang(Mengfan),Li(Yujing),Zhang(Xiya),Deng(Ti… J Biol Chem 2015-03-03

...BRCA1 foci, as well as less efficient non-homologous end joining (NHEJ) and elevated levels of homologous recombination ...

DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA…

Klajic(Jovana),Busato(Florence),Edvardsen(He… Clin Cancer Res 2015-11-17

...BRCA1, FOXC1, and IGFBP3, and most notably repetitive elements like ALU and LINE1, were associated with TP53 mutations s...

Impact of α-targeted radiation therapy on gene expression in a pre-clinical mod…

Yong(Kwon Joong),Milenic(Diane E),Baidoo(Kwa… PLoS One 2015-06-08

...BRCA1, CIDEA, GADD45α, GADD45γ, GML, IP6K3, PCBP4, PPP1R15A, RAD21, and p73), cell cycle (BRCA1, CHK1, CHK2, GADD45α, GM...

Stabilization and targeting of INO80 to replication forks by BAP1 during normal…

Lee(Han-Sae),Lee(Shin-Ai),Hur(Shin-Kyoung),S… Nat Commun 2015-12-15

...BRCA1-associated protein-1 (BAP1), a tumour suppressor and nuclear de-ubiquitinating enzyme that also functions to stabi...

Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA …

Wei(Na),Shi(Yi),Truong(Lan N),Fisch(Kathleen… Mol Cell 2015-01-09

...BRCA1 and RAD51. The activation is achieved through direct interaction of TyrRS with TRIM28 to sequester this vertebrate...

An update on PARP inhibitors--moving to the adjuvant setting.

Sonnenblick(Amir),de Azambuja(Evandro),Azim(… Nat Rev Clin Oncol 2015-07-30

...BRCA1 or BRCA2 mutations. Since the development of first-generation PARP inhibitors more than a decade ago, numerous cli...

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