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Nrf2, the master redox switch: the Achilles' heel of ovarian cancer?

van der Wijst(Monique G P),Brown(Robert),Rot… Biochim Biophys Acta 2015-02-12

...BRCA1 and its link with estradiol, TP53) for future NRF2 targeting strategies.

A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1…

Kononenko(Artem V),Bansal(Ruchi),Lee(Nichola… Nucleic Acids Res 2015-01-27

...BRCA1. At the same time some functional aspects of BRCA1 are not fully understood. Here, a HAC (human artificial chromos...

BRCA1 accelerates CtIP-mediated DNA-end resection.

Cruz-García(Andrés),López-Saavedra(Ana),Huer… Cell Rep 2015-07-24

...BRCA1. The role of BRCA1 in DNA-end resection is not clear. Here, we develop an assay to study DNA resection in higher e...

Use of risk-reducing surgeries in a prospective cohort of 1,499 BRCA1 and BRCA2…

Chai(Xinglei),Friebel(Tara M),Singer(Christi… Breast Cancer Res Treat 2015-07-14

...BRCA1 and 71% for BRCA2 by age 50. RRM usage was estimated to be 46% by age 70 in both BRCA1 and BRCA2 carriers. BRCA1 m...

Addressing sexual dysfunction after risk-reducing salpingo-oophorectomy: effect…

Bober(Sharon L),Recklitis(Christopher J),Bak… J Sex Med 2015-06-29

Women at high risk for ovarian cancer due to BRCA1 or BRCA2 mutation or family history are recommended to undergo risk-r...

[Function of CDK12 in Tumor initiation and progression and its clinical consequ…

Vrábel(D),Svoboda(M),Navrátil(J),Kohoutek(J) Klin Onkol 2015-06-18

...BRCA1, ATM, ATR, FANCI and FANCD2, which are involved in the DNA-damage response pathway. Importantly, inhibition of fun...

Establishment and characterization of a receptor-negative, hormone-nonresponsiv…

Al-Shammari(Ahmed Majeed),Alshami(Mortadha A… Breast Cancer (Dove Med Press) 2015-08-24

...BRCA1 and BRCA2, as well as for vimentin. This cell line should be useful when testing new therapies for breast cancer i...

miRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) hereditar…

Tanić(Miljana),Yanowski(Kira),Andrés(Eduardo… Genom Data 2015-10-20

...BRCA1 or BRCA2 gene, while mutations in other rare high and moderate-risk genes and common low penetrance variants may a...

Clinical Application of Multigene Panels: Challenges of Next-Generation Counsel…

Slavin(Thomas Paul),Niell-Swiller(Mariana),S… Front Oncol 2015-10-20

...BRCA1, BRCA2, MSH6, PMS2, TP53, APC, CDH1), the results would have been positive only 6.2% of the time, instead of 17%. ...

The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cance…

Cavanagh(Helen),Rogers(Katherine M A) Hered Cancer Clin Pract 2015-08-03

...BRCA1/2 with cancers at other sites within the body. This review examines the association of BRCA1/2 germline gene mutat...

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