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Functional analysis of familial Asp67Glu and Thr1051Ser BRCA1 mutations in brea…

Pongsavee(Malinee),Patmasiriwat(Pimpicha),Sa… Int J Mol Sci 2014-07-15

Estrogen is believed to be pre-initiator in the risk of breast cancer. The BRCA1 is a tumor suppressor gene associated w...

Molecular profiling of human mammary gland links breast cancer risk to a p27(+)…

Choudhury(Sibgat),Almendro(Vanessa),Merino(V… Cell Stem Cell 2014-01-30

...BRCA1 or BRCA2 mutations. We found significant differences in CD44(+) progenitor cells, where the levels of many stem ce...

Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis…

Silva(N),Adamo(A),Santonicola(P),Martinez-Pe… Cell Death Differ 2014-03-31

...BRCA1), irrespectively of the amount of DSBs present in pachytene nuclei. Although ionizing radiation fails to induce ap...

Knowledge, attitudes and behavior of physicians regarding predictive genetic te…

Marzuillo(Carolina),De Vito(Corrado),Boccia(… Prev Med 2014-06-12

...BRCA1/2 and APC tests.,A cross-sectional survey of a random sample of Italian physicians was performed in 2010 through a...

Can unknown predisposition in familial breast cancer be family-specific?

Lynch(Henry),Wen(Hongxiu),Kim(Yeong C),Snyde… Breast J 2014-06-20

...BRCA1-, BRCA2-, p53-, and PTEN-negative breast cancer family, of which five had breast cancer, one is an obligate gene c...

Contralateral mastectomy improves survival in women with BRCA1/2-associated bre…

Evans(D Gareth R),Ingham(Sarah L),Baildam(An… Breast Cancer Res Treat 2014-02-10

BRCA1/2 mutation carriers with breast cancer are at high risk of contralateral disease. Such women often elect to have c...

Comparative antiproliferative effects of iniparib and olaparib on a panel of tr…

Pierce(Aisling),McGowan(Patricia M),Cotter(M… Cancer Biol Ther 2014-01-14

...BRCA1 or miR-182. Combined addition of olaparib and either the CDK1 inhibitor, RO-3306 or a pan HER inhibitor (neratinib...

Oocyte heterogeneity with respect to the meiotic silencing of unsynapsed X chro…

Taketo(Teruko),Naumova(Anna K) Chromosoma 2014-03-26

...BRCA1, γH2AX, H3K9me3, and H3K27me3, at the single X chromosome in the XY oocyte. We found that γH2AX and BRCA1 were enr...

Constitutional CHEK2 mutations are infrequent in early-onset and familial breas…

Rashid(Muhammad U),Muhammad(Noor),Faisal(Sai… BMC Cancer 2014-01-10

...BRCA1, BRCA2 and TP53. Thus, mutations in other genes confer genetic susceptibility to breast cancer, of which CHEK2 is ...

Pattern of breast cancer susceptibility gene 1 expression is a potential progno…

Wang(Tong),Wentz(Sabrina C),Ausborn(Natalie … Pancreas 2014-02-13

...BRCA1 distribution was associated with higher pathologic stage (P = 0.006). Nuclear-cytosolic BRCA1 distribution was ass...

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