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Identification of domains of BRCA1 critical for the ubiquitin-dependent inhib...

Sankaran(Satish),Starita(Lea M),Simons(Ama... Cancer Res 2006-06-07

...BARD1, has multiple functions aimed at maintaining genomic stability in the cell. We have shown earlier that the BRCA1/B...

Direct stimulation of transcription initiation by BRCA1 requires both its ami...

Horwitz(Andrew A),Sankaran(Satish),Parvin(... J Biol Chem 2006-05-23

...BARD1, is not. Our data support a model whereby BRCA1 stabilizes productive preinitiation complexes and thus stimulates ...

BRCA1 DNA-binding activity is stimulated by BARD1.

Simons(Amanda M),Horwitz(Andrew A),Starita... Cancer Res 2006-04-13

...BARD1 heterodimer. Because nuclear BRCA1 exists as a heterodimer with BARD1, it is likely that in vitro studies of the h...

Substrates of the BRCA1-dependent ubiquitin ligase.

Starita(Lea M),Parvin(Jeffrey D) Cancer Biol Ther 2006-06-22

...BARD1, comprise an E3 ubiquitin ligase. Since it is now known that BRCA1 is an enzyme, the challenge for BRCA1 research ...

Soya phytonutrients act on a panel of genes implicated with BRCA1 and BRCA2 o...

Caëtano(Bertrand),Le Corre(Ludovic),Chalab... Br J Nutr 2006-03-14

...BARD1, JUN, BAX, RB1, ERalpha, ERbeta, BAP1, TNFalpha, p53, p21Waf1/Cip1, p300, RAD51, pS2, Ki-67) were quantified by re...

Homologous recombination is required for genome stability in the absence of D...

Youds(Jillian L),O'Neil(Nigel J),Rose(Ann ... Genetics 2006-09-08

...BARD1, RAD51, and XPF and the trans-lesion synthesis polymerases poleta and polkappa contribute to the prevention of del...

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage ...

Polanowska(Jolanta),Martin(Julie S),Garcia... EMBO J 2006-07-21

The BRCA1 tumour suppressor and its heterodimeric partner BARD1 constitute an E3-ubiquitin (Ub) ligase and function in D...

BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of...

Kleiman(Frida E),Wu-Baer(Foon),Fonseca(Dan... Genes Dev 2005-06-20

...BARD1 ubiquitin ligase activity. Significantly, siRNA-mediated knockdown of BRCA1 and BARD1 resulted in stabilization of...

Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking.

Henderson(Beric R) Bioessays 2005-11-15

The subcellular location and function of many proteins are regulated by nuclear-cytoplasmic shuttling. BRCA1 and BARD1 p...

BARD1 expression during spermatogenesis is associated with apoptosis and horm...

Feki(Anis),Jefford(Charles Edward),Jefford... Biol Reprod 2005-02-22

...BARD1 mRNA, later stages of spermatocyte precursors express predominantly a novel, shorter splice form BARD1beta. BARD1b...

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