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Disclosure pattern and follow-up after the molecular diagnosis of BRCA/CHEK2 mu…

Kegelaers(D),Merckx(W),Odeurs(P),van den End… J Genet Couns 2014-11-14

Five to 10% of all breast cancer cases are due to mutations of high penetrance susceptibility genes, especially BRCA1 an...

Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial …

Zhang(Zhan),Lu(Huiyuan),Huan(Fei),Meghan(Cro… Int J Cancer 2014-04-17

...BRCA1, Mre11, Rad50 and Rad51. However, the apoptosis of P40 cells was near normal, while the expression of Bax, C-Caspa...

Association of somatic DNA methylation variability with progression-free surviv…

Flanagan(J M),Wilhelm-Benartzi(C S),Metcalf(… Ann Oncol 2014-06-02

...BRCA1), secreted frizzled-related protein 1 (SFRP1), stratifin (SFN), retinoic acid receptor beta (RARB) loci and the re...

The psychological impact of breast and ovarian cancer preventive options in BRC…

Borreani(C),Manoukian(S),Bianchi(E),Brunelli… Clin Genet 2014-07-18

This study was performed to describe the impact of preventive options on the psychological condition of BRCA1/BRCA2 carr...

Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated me…

Lin(Li-Fang),Li(Chien-Feng),Wang(Wei-Jan),Ya… PLoS One 2014-06-15

ZBRK1, a zinc finger protein that interacts with breast cancer 1 (BRCA1) and KRAB-ZFP-associated protein 1 (KAP1), has b...

Association of BRCA1 germline mutations in young onset triple-negative breast c…

Andrés(R),Pajares(I),Balmaña(J),Llort(G),Ram… Clin Transl Oncol 2014-10-09

BRCA1-associated breast cancers have been associated to a triple-negative phenotype. The prevalence of BRCA1 germline mu...

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 t…

Kakarougkas(Andreas),Ismail(Amani),Katsuki(Y… Nucleic Acids Res 2014-02-13

...BRCA1 IRIF forming between 53BP1 and replication protein A (RPA). Ubiquitin chains assessed using α-FK2 antibodies are s...

BRCA sequencing and large rearrangement testing in young Black women with breas…

Pal(Tuya),Bonner(Devon),Cragun(Deborah),John… J Community Genet 2014-03-17

...BRCA1 and BRCA2 (BRCA) gene mutations. In a cancer registry-based sample of young Black women with breast cancer, we eva...

Lack of referral for genetic counseling and testing in BRCA1/2 and Lynch syndro…

Pujol(P),Lyonnet(D Stoppa),Frebourg(T),Blin(… Breast Cancer Res Treat 2014-04-15

...BRCA1/2 or MMR genes mutation. Genetic testing and consultations for familial high-risk individuals are exclusively fund...

Added value of family history in counseling about risk of BRCA1/2 mutation in e…

Arts-de Jong(Marieke),Manders(Catharina M),H… Int J Gynecol Cancer 2014-07-08

...BRCA1/2 mutation at our department of human genetics between 1996 and 2012 were included. The rate of BRCA1/2 mutation w...

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