...BRCA1 (n = 106) or BRCA2 (n = 32) mutations. BRCA mutation prevalence differed by ethnicity and race: AA (20.4 %), AJ (5...
...BRCA1/2 pathogenic mutations occurring in the Greek population. An overall mutation prevalence of 32% was observed. Six ...
...BRCA1, suppression of HR and NHEJ repair activity, and downregulation of the expressions and DNA-end binding activities ...
...BRCA1 recruitment; and (iv) activation of the NHEJ pathway, which selectively induces error-prone repair in HR-deficient...
...BRCA1 mutations: 5382insC, C61G and 4153delA. To date, just a few single large genomic rearrangements (LGRs) of BRCA1 ge...
...BRCA1 rs799917 also had higher EJ capacity (35.1 ± 9.2 %) than those with GG (26.4 ± 10.1 %, p = 0.02).,Overall, we foun...
...BRCA1/2, and the activation of the cell cycle regulatory enzymes ATM and ATR. (2) PARP inhibitors as a single agent have...
...BRCA1, ATP7B, PKM2 TOPOI, TOPOIIA, TOPOIIB and C-MYC mRNA expression. All patients were treated with cisplatin-etoposide...
...BRCA1/2 mutations can be identified, and screening and prevention strategies can be used before a diagnosis of cancer oc...
...BRCA1/2 mutation carriers (mean age, 43 years) and 16 women postmantle irradiation (mean age 40 years) underwent diffusi...
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