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TP53 BRCA1 CRISPR single-cell cancer

Pothuri(B) Ann Oncol 2014-05-13

...BRCA1/2 gene mutations account for ~10%-12% of ovarian cancers. The BRCA1/2 proteins are important in homologous recombi...

Dubeau(L),Drapkin(R) Ann Oncol 2014-05-13

...BRCA1 or BRCA2 mutation carriers. These studies showed that a significant majority of high-grade serous ovarian carcinom...

Bonanni(B),Lazzeroni(M) Ann Oncol 2014-05-13

...BRCA1/2 germline mutation, the psychological and clinical factors implicated in decision making about a trial, and the p...

Gadducci(A),Sergiampietri(C),Tana(R) Ann Oncol 2014-05-13

BRCA1 and BRCA2 mutation carriers have an 18%-60% and 11%-27% lifetime risk of developing ovarian carcinoma, respectivel...

Safra(T),Lai(W C),Borgato(L),Nicoletto(M O),… Ann Oncol 2014-05-13

...BRCA1/2 carriers (71 BRCA1 and 19BRCA2). The most common mutations in AJ and non-AJ origins were 185delAG and 6174delT. ...

Barcellos-Hoff(M H),Kleinberg(D L) Ann Oncol 2014-05-13

...BRCA1 mutations has been an area of intense study for three reasons. First, BRCA1 was the first gene shown to associate ...

Lynch(H T),Snyder(C),Casey(M J) Ann Oncol 2014-05-13

...BRCA1 and BRCA2 as being responsible for hereditary BC and OC (HBOC) in many women with early-onset HBOC. More recently,...

Vikrant,Kumar(Rajan),Yadav(Lumbini R),Nakhwa… PLoS One 2014-06-15

...BRCA1 complex at the damage site. Nevertheless, how RAP80 helps in the structural integrity of BRCA1 complex is still el...

Birkenkamp-Demtröder(Karin),Hahn(Stephan A),… PLoS One 2014-07-02

...BRCA1. Knockdown of KRT23 rendered colon cancer cells more sensitive to irradiation and reduced proliferation of the KRT...

Cron(Kyle R),Zhu(Kaya),Kushwaha(Deepa S),Hsi… PLoS One 2014-07-02

...BRCA1 and FANCD2, and a reduction of BRCA1, FANCD2 and RAD51 ionizing radiation-induced foci. IκBα RNAi knockdown rescue...

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