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Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar…

Daino(Kazuhiro),Imaoka(Tatsuhiko),Morioka(Ta… PLoS One 2014-06-15

...BRCA1 and plays an important role in BRCA1-dependent DNA repair and DNA damage-induced checkpoint control. Recent studie...

Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated me…

Lin(Li-Fang),Li(Chien-Feng),Wang(Wei-Jan),Ya… PLoS One 2014-06-15

ZBRK1, a zinc finger protein that interacts with breast cancer 1 (BRCA1) and KRAB-ZFP-associated protein 1 (KAP1), has b...

Association of BRCA1 germline mutations in young onset triple-negative breast c…

Andrés(R),Pajares(I),Balmaña(J),Llort(G),Ram… Clin Transl Oncol 2014-10-09

BRCA1-associated breast cancers have been associated to a triple-negative phenotype. The prevalence of BRCA1 germline mu...

The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cob…

Ichim(Gabriel),Genevois(Anne-Laure),Ménard(M… Mol Cell 2014-01-06

...BRCA1, and that Cobra1 is required for TrkC-induced apoptosis. We also show that, in the developing chick neural tube, N...

Short telomeres are frequent in hereditary breast tumors and are associated wit…

Martinez-Delgado(Beatriz),Gallardo(Mercedes)… Breast Cancer Res Treat 2014-05-08

...BRCA1, n = 14; BRCA2, n = 13; non-BRCA1/2, n = 48) and 29 sporadic tumors were analyzed. Assessment of telomere signal i...

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 t…

Kakarougkas(Andreas),Ismail(Amani),Katsuki(Y… Nucleic Acids Res 2014-02-13

...BRCA1 IRIF forming between 53BP1 and replication protein A (RPA). Ubiquitin chains assessed using α-FK2 antibodies are s...

BRCA sequencing and large rearrangement testing in young Black women with breas…

Pal(Tuya),Bonner(Devon),Cragun(Deborah),John… J Community Genet 2014-03-17

...BRCA1 and BRCA2 (BRCA) gene mutations. In a cancer registry-based sample of young Black women with breast cancer, we eva...

Lack of referral for genetic counseling and testing in BRCA1/2 and Lynch syndro…

Pujol(P),Lyonnet(D Stoppa),Frebourg(T),Blin(… Breast Cancer Res Treat 2014-04-15

...BRCA1/2 or MMR genes mutation. Genetic testing and consultations for familial high-risk individuals are exclusively fund...

Added value of family history in counseling about risk of BRCA1/2 mutation in e…

Arts-de Jong(Marieke),Manders(Catharina M),H… Int J Gynecol Cancer 2014-07-08

...BRCA1/2 mutation at our department of human genetics between 1996 and 2012 were included. The rate of BRCA1/2 mutation w...

Prevalence of BRCA mutations among women with triple-negative breast cancer (TN…

Greenup(Rachel),Buchanan(Adam),Lorizio(Wendy… Ann Surg Oncol 2014-04-15

...BRCA1 (n = 106) or BRCA2 (n = 32) mutations. BRCA mutation prevalence differed by ethnicity and race: AA (20.4 %), AJ (5...

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