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Streamlined ion torrent PGM-based diagnostics: BRCA1 and BRCA2 genes as a model.

Tarabeux(Julien),Zeitouni(Bruno),Moncoutier(… Eur J Hum Genet 2014-11-18

...BRCA1/2 sequencing. The procedure was first tested on a training set of 62 control samples, and then blindly validated o...

Comparison of whole genome amplification and nested-PCR methods for preimplanta…

Michalska(Danuta),Jaguszewska(Kinga),Liss(Jo… Hered Cancer Clin Pract 2014-05-20

...BRCA1 gene mutations: 5382insC, 185delAG and C61G.,Anonymous donors of the oocytes and control healthy blood samples wer...

Histone deacetylase regulation of ATM-mediated DNA damage signaling.

Thurn(K Ted),Thomas(Scott),Raha(Paromita),Qu… Mol Cancer Ther 2014-05-19

...BRCA1, CHK2, and p53 leading to the induction of response genes such as CDKN1A (p21), GADD45A, and RRM2B that promote ce...

Overabundant FANCD2, alone and combined with NQO1, is a sensitive marker of adv…

Fagerholm(R),Sprott(K),Heikkinen(T),Bartkova… Ann Oncol 2014-06-02

...BRCA1, FANCD2, RAD51, XPF, and PAR in relation to clinicopathological and survival data among 1240 paraffin-embedded bre...

Hereditary genes and SNPs associated with breast cancer.

Mahdi(Kooshyar Mohammad),Nassiri(Mohammad Re… Asian Pac J Cancer Prev 2014-02-19

...BRCA1, BRCA2, PTEN, ATM, TP53, CHEK2, PPM1D, CDH1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, BRIP1, RAD50, RAD51C...

Progesterone receptor A stability is mediated by glycogen synthase kinase-3β in…

Wang(Shaohui),Li(Ying),Hsu(Pang-Hung),Lee(So… J Biol Chem 2014-02-04

...Brca1-deficient mammary epithelial cells, and treating with anti-progesterone delays mammary tumorigenesis in Brca1/p53 ...

BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human…

Shen(Yuqiao),Rehman(Farah L),Feng(Ying),Bosh… Clin Cancer Res 2014-09-01

...BRCA1, BRCA2, or PTEN gene defects with 20- to more than 200-fold greater potency than existing PARP1/2 inhibitors. BMN ...

Differential chemotherapeutic sensitivity for breast tumors with "BRCAness": a …

Chalasani(Pavani),Livingston(Robert) Oncologist 2014-05-06

BRCA1 or BRCA2 mutations predispose to cancer development, primarily through their loss of role in the repair of DNA dou...

Mutation analysis of the BCCIP gene for breast cancer susceptibility in breast/…

Bonache(Sandra),Gutierrez-Enriquez(Sara),Ten… Gynecol Oncol 2014-01-06

...BRCA1 and BRCA2 genes explain less than 25% of the familial clustering of breast cancer, and additional susceptibility g...

TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.

Fam(Hok Khim),Walton(Cheryl),Mitra(Sheetal A… Mol Cancer Res 2014-05-28

...BRCA1/2 mutations or altered expression was not detectable in rhabdomyosarcoma cells; however, TDP1 knockdown and PARP-1...

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