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Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in...

Rodriguez(José Antonio),Au(Wendy W Y),Hend... Exp Cell Res 2004-03-11

...BARD1. We propose that BRCT mutations alter nuclear targeting of BRCA1, and that this may contribute to the inhibition o...

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, depen...

Morris(Joanna R),Solomon(Ellen) Hum Mol Genet 2004-11-30

...BARD1. In this report we use an immunohistochemical approach to demonstrate the association of cellular BRCA1 with the e...

Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin ...

Nishikawa(Hiroyuki),Ooka(Seido),Sato(Ko),A... J Biol Chem 2004-04-01

...BARD1 in vitro. BRCA1-BARD1 preferentially utilizes ubiquitin with a single Lys residue at Lys-6 or Lys-29 to mediate au...

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a sig...

Dong(Yuanshu),Hakimi(Mohamed-Ali),Chen(Xia... Mol Cell 2004-01-05

...BARD1/BRCC45/BRCC36 revealed an enhanced E3 ligase activity compared to that of BRCA1/BARD1 heterodimer. In vivo, deplet...

An adenoviral vector containing an arg-gly-asp (RGD) motif in the fiber knob ...

Campbell(Mel),Qu(Shimian),Wells(Sam),Sugan... Cancer Gene Ther 2004-02-26

...BARD1 and this functional effect was evident at lower input viral doses when BRCA1 was delivered via the RGD-modified Ad...

Targets of 17beta-oestradiol-induced apoptosis in colon cancer cells: a mecha...

Qiu(Yan),Langman(Michael J S),Eggo(Margare... J Endocrinol 2004-07-16

...BARD1. By comparing control arrays from the two cell populations, cAMP-response element-binding protein (CBP), which is ...

Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, ...

Reinholz(Monica M),An(Ming-Wen),Johnsen(St... Breast Cancer Res Treat 2004-11-16

...Bard1 using real-time RT/PCR in 14 normal breast, five non-invasive, 57 invasive (including 29 with outcome data), and f...

Physical mechanisms and biological significance of supramolecular protein sel...

Kentsis(Alex),Borden(Katherine L B) Curr Protein Pept Sci 2004-10-26

...BARD1 with regard to assembly of supramolecular enzymes with metabolic and chemically directive functions. In addition t...

Nuclear-cytoplasmic translocation of BARD1 is linked to its apoptotic activit...

Jefford(Charles Edward),Feki(Anis),Harb(Je... Oncogene 2004-06-01

...BARD1 plays a dual role in response to genotoxic stress: DNA repair as a BARD1-BRCA1 heterodimer and induction of apopto...

Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is r...

Choudhury(Atish D),Xu(Hong),Baer(Richard) J Biol Chem 2004-10-25

...BARD1 inhibits the formation of these conjugates, suggesting that BARD1 serves to stabilize BRCA1 expression in part by ...

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