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DNA damage response genes and the development of cancer metastasis.

Broustas(Constantinos G),Lieberman(Howard B) Radiat Res 2014-05-02

...BRCA1, ATM and TP53 have been associated with metastasis by a number of in vitro biochemical and cellular assays, by exa...

Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting …

Konstantinopoulos(Panagiotis A),Wilson(Andre… Gynecol Oncol 2014-07-16

...BRCA1null and UWB1.289+BRCA1 wild-type) were treated with saline vehicle, olaparib, SAHA or olaparib/SAHA. Sulforhodamin...

Decision-making on preimplantation genetic diagnosis and prenatal diagnosis: a …

Derks-Smeets(I A P),Gietel-Habets(J J G),Tib… Hum Reprod 2014-12-15

How do couples with a BRCA1/2 mutation decide on preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND) fo...

Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A…

Leung(Justin W),Agarwal(Poonam),Canny(Marell… PLoS Genet 2014-11-25

...BRCA1 recruitment to DNA damage. The acidic patch therefore is a critical nucleosome feature that may serve as a scaffol...

Mitochondrial DNA variants and risk of familial breast cancer: an exploratory s…

Tommasi(Stefania),Favia(Paola),Weigl(Stefani… Int J Oncol 2014-11-13

...BRCA1/BRCA2 mutations, 14 sporadic BC patients and 20 healthy subjects were analyzed. In the D-loop and in the MTND4 reg...

Variants in the ATM-CHEK2-BRCA1 axis determine genetic predisposition and clini…

Wójcicka(Anna),Czetwertyńska(Małgorzata),Świ… Genes Chromosomes Cancer 2014-10-10

...BRCA1 variant by 0.78 (P = 0.02). Both the ATM and BRCA1 variants modify the impact of male gender on clinical variables...

Specific BRCA1 gene variations amongst young Moroccan breast cancer patients.

Tazzite(A),Nadiffi(S),Kottwitz(D),El Amrani(… Genet Mol Res 2014-11-04

...BRCA1 mutations in Moroccan breast cancer patients. We here present an analysis of BRCA1 gene regions (exon 2 and exon 1...

Clinical interpretation and implications of whole-genome sequencing.

Dewey(Frederick E),Grove(Megan E),Pan(Cuipin… JAMA 2014-03-31

...BRCA1 gene implicated in hereditary breast and ovarian cancer. Physician review of sequencing findings prompted consider...

The clinical utility of genetic testing in breast cancer kindreds: a prospectiv…

Møller(Pål),Stormorken(Astrid),Holmen(Marit … Breast Cancer Res Treat 2014-11-18

...BRCA1/2 mutation. According to family history, the optimal available member(s) of each breast cancer kindred attending o...

PARP3 affects the relative contribution of homologous recombination and nonhomo…

Beck(Carole),Boehler(Christian),Guirouilh Ba… Nucleic Acids Res 2014-07-15

...BRCA1 and 53BP1. Both events result in compromised accurate C-NHEJ and a concomitant increase in DNA end resection. Neve...

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