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Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated…

O'Sullivan(Ciara C),Moon(Dominic H),Kohn(Eli… Front Oncol 2014-06-24

...BRCA1/2 mutation (gBRCAm)-associated breast and ovarian cancers. Accumulating evidence suggests that PARPi may have a wi...

Reversing Platinum Resistance in High-Grade Serous Ovarian Carcinoma: Targeting…

Wiedemeyer(W Ruprecht),Beach(Jessica A),Karl… Front Oncol 2014-06-24

...BRCA1 and BRCA2 in particular, as main determinants of response to platinum therapy. BRCA-mutant ovarian cancers are esp...

TP53 p.R337H prevalence in a series of Brazilian hereditary breast cancer famil…

Cury(Nathalia M),Ferraz(Victor Ef),Silva(Wil… Hered Cancer Clin Pract 2014-03-20

...BRCA1 and BRCA2 genes and is characterized by breast adenocarcinoma and/or epithelial ovarian carcinoma. LFS is associat...

Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-a…

Gardini(Alessandro),Baillat(David),Cesaroni(… EMBO J 2014-06-03

Breast and ovarian cancer susceptibility genes BRCA1 and PALB2 have enigmatic roles in cellular growth and mammalian dev...

Association of BRCA1 K1183R polymorphism with survival in BRCA1/2-negative chin…

Pei(Renguang),Wang(Peng),Zhou(Yunfeng),Zhang… Clin Lab 2014-03-31

...BRCA1 K1183R polymorphism (3667A > G) affects survival in BRCA1/2-negative Chinese familial breast cancer. We investigat...

A novel deleterious PTEN mutation in a patient with early-onset bilateral breas…

Pradella(Laura Maria),Evangelisti(Cecilia),L… BMC Cancer 2014-09-02

...BRCA1/2 mutations are only found in a minority of younger BC patients. Among the others, a fraction may carry mutations ...

Telomere length shows no association with BRCA1 and BRCA2 mutation status.

Killick(Emma),Tymrakiewicz(Malgorzata),Cieza… PLoS One 2014-09-29

...BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carri...

Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confi…

Whiley(Phillip J),Parsons(Michael T),Leary(J… PLoS One 2014-12-22

Rare exonic, non-truncating variants in known cancer susceptibility genes such as BRCA1 and BRCA2 are problematic for ge...

Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD5…

Cunningham(J M),Cicek(M S),Larson(N B),Davil… Sci Rep 2014-10-10

...BRCA1 and four (1.4%) in BRCA2. Fifty two patients (10.8%) had methylated BRCA1 or RAD51C. HRD patients with germline or...

Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast can…

Li(Da),Bi(Fang-Fang),Cao(Ji-Min),Cao(Chen),L… Mol Cancer 2014-09-08

...BRCA1-mutated breast cancer patients.,Our findings imply that genetic (such as BRCA1 mutation) and epigenetic mechanisms...

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