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Phosphorylation near nuclear localization signal regulates nuclear import of ad…

Zhang(F),White(RL),Neufeld(KL) Proc Natl Acad Sci U S A 2000-11-07

...APC)) and 2048-2053 (NLS2(APC)). Both APC NLSs are well conserved among human, mouse, rat, and fly. NLS1(APC) and NLS2(A...

Critical role for the EB1 and APC interaction in the regulation of microtubule …

Nakamura(M),Zhou(XZ),Lu(KP) Curr Biol 2001-07-10

...APC. EB1 also interacts with the plus-ends of microtubules and targets APC to microtubule tips. Since APC is detected on...

Identification of divalent metal ion-dependent inhibition of activated protein …

Heeb(MJ),Gruber(A),Griffin(JH) J Biol Chem 1991-09-15

...APC-protein C inhibitor (APC-PCI) and APC-alpha 1-antitrypsin complexes. Whole blood contained two additional APC-inhibi...

Recombinant murine-activated protein C is neuroprotective in a murine ischemic …

Fernández(JA),Xu(X),Liu(D),Zlokovic(BV),Grif… Blood Cells Mol Dis 2003-00-00

...APC were studied in an ischemic stroke model. Both human APC and mouse APC prolonged the activated partial thromboplasti...

Impaired APC cofactor activity of factor V plays a major role in the APC resist…

Castoldi(E),Brugge(JM),Nicolaes(GA),Girelli(… Blood 2004-06-01

...APC and impaired APC cofactor activity contributed equally to FV(Leiden)-associated APC resistance, whereas FV(R2)-assoc...

The armadillo repeat domain of Apc suppresses intestinal tumorigenesis.

Crist(RC),Roth(JJ),Baran(AA),McEntee(BJ),Sir… Mamm Genome 2010-10-00

...APC mutation, indicating a complex role for APC that extends beyond the canonical WNT pathway. APC encodes a large prote...

APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mi…

Uzunova(K),Dye(BT),Schutz(H),Ladurner(R),Pet… Nat Struct Mol Biol 2012-11-00

...APC15, a human APC/C subunit related to yeast Mnd2. APC15 is located near APC/C's MCC binding site; it is required for A...

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to an…

Listovsky(T),Sale(JE) J Cell Biol 2013-10-14

...APC/C. Loss of MAD2L2 led to premature association of CDH1 with the APC/C, early destruction of APC/C(CDH1) substrates, ...

Wild-type APC Is Associated with Poor Survival in Metastatic Microsatellite Sta…

Wang(C),Ouyang(C),Cho(M),Ji(J),Sandhu(J),Goe… Oncologist 2021-00-00

...APC (APC-WT) in microsatellite stable (MSS) metastatic colorectal cancer (mCRC) is not well defined. APC prognostic valu...

Dissecting interactions between EB1, microtubules and APC in cortical clusters …

Barth(AI),Siemers(KA),Nelson(WJ) J Cell Sci 2002-04-15

...APC that lack EB1- and MT-binding domains are necessary and sufficient for APC localization in cortical clusters; an APC...

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