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L Antigen Family Member 3 stabilizes stalled replication forks by reducing MRE1…

Lyu(M),Yang(G),Jia(S),Zhang(X),Li(Y),Feng(Y)… Nucleic Acids Res 2026-08-24

...MRE11 nuclease as a LAGE3-interacting partner, and LAGE3 deficiency leads to unscheduled stalled forks degradation in an...

Uncovering Hereditary Risk: Germline Homologous Recombination Repair Variant Sp…

Kapoor(A),Uthale(S),Chain(A),Rungta(A),Anoop… JCO Glob Oncol 2026-08-00

...MRE11, and FANCC. Of 950 patients analyzed, 364 (38.3%) harbored variants in HRR genes, with 266 (28%) carrying pathogen...

A dual-dimensional CRISPR toolkit enables one-step high-efficiency multiplex ge…

Yu(Z),Chen(K),Maimaitirexiati(G),Bai(Z),Li(S… Metab Eng 2026-08-13

...MRE11(The endogenous MRE11 gene from Pichia pastoris) overexpression (The Meiotic Recombination 11, DNA double-strand br...

Inflammatory kinase TBK1 suppresses homologous recombination DNA repair to sens…

Zhou(W),Wang(X),Steigleder(SS),Xing(A),Yang(… Proc Natl Acad Sci U S A 2026-08-18

...MRE11) to PARP1 at DNA-damage sites in a kinase-activity-dependent yet cytokine-independent manner. Furthermore, TBK1 ac...

Targeting PKM2 and GAPDH by baicalein and corilagin from TCM reduces lactylatio…

Li(C),Cui(Z),Sun(W),Liu(W),Deng(S),Cao(J),Ca… Phytomedicine 2026-10-00

...MRE11 being particularly affected. This study established a natural product-based targeting strategy, identifying baical...

Cellular Retinoic Acid-Binding Protein 2 Promotes Ischemia-Induced Cardiac Fibr…

Su(Z),Shen(H),Sun(J),Kong(X),Sun(W) J Am Heart Assoc 2026-08-04

...MRE11/MRE11-RAD50-NBS1 (MRN) perturbation. Single-cell analyses identify CRABP2 as a fibroblast-enriched gene upregulate...

MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice.

Lukaszewicz(A),Wilson(TE),Kim(S),Keeney(S),J… Genes Dev 2026-08-26

...MRE11-deficient mouse spermatocytes, which do not resect their DSBs, deletions at double cuts occur readily, with end-jo...

CRISPR Screening Identifies SMARCAL1 and MRN as Modulators of WRN Dependency in…

Ma(T),Wu(J),Li(S),Chen(J) Cancer Res 2026-07-22

...MRE11-RAD50-NBS1 (MRN) complex, rather than MUS81 or ERCC1/XPF, was the principal mediator of cruciform DNA processing f...

RNF126 in Physiology and Disease: A Multifunctional RING-Type E3 Ubiquitin Liga…

Vu(AD),Mori(S),Sakamoto(T) Cells 2026-06-25

...MRE11, Ku80, RNF168, and 14-3-3σ. Genetic studies have further demonstrated its importance in embryogenesis and male fer...

Chromatin Nano-Organization in Peripheral Blood Mononuclear Cells After In-Solu…

Schäfer(M),Muhtadi(R),Schumann(S),Bestvater(… Biomolecules 2026-01-13

...MRE11 and pATM in the chromatin regions surrounding a DSB. Furthermore, local changes in spatial H3K9me3 heterochromatin...

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