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Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase.

Sato(Ko),Hayami(Ryosuke),Wu(Wenwen),Nishik... J Biol Chem 2004-09-21

...BARD1 both identified NPM. NPM interacts with N-terminal fragments of BRCA1 and BARD1 in a manner dependent upon BRCA1-B...

BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear ret...

Fabbro(Megan),Schuechner(Stefan),Au(Wendy ... Exp Cell Res 2004-10-04

...BARD1 reduced BRCA1-dependent apoptosis by a mechanism involving nuclear sequestration. Regulation of apoptosis by BARD1...

Ubiquitin and breast cancer.

Ohta(Tomohiko),Fukuda(Mamoru) Oncogene 2004-04-13

...BARD1; ErbB2/HER2/Neu and its ubiquitin ligase c-Cbl or CHIP; and the estrogen receptor and its downstream target Efp. U...

Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activi...

Rodriguez(José Antonio),Schüchner(Stefan),... Oncogene 2004-05-13

...BARD1 has a BRCA1-independent proapoptotic activity; however, little is known about its regulation. Here, we show that B...

Genetic steps of mammalian homologous repair with distinct mutagenic conseque...

Stark(Jeremy M),Pierce(Andrew J),Oh(Jin),P... Mol Cell Biol 2004-12-03

...BARD1 had effects similar to those of mutation of BRCA1. Thus, BRCA1/BARD1 has a role in homologous repair before the br...

Identification of BRCA1-IRIS, a BRCA1 locus product.

ElShamy(Wael M),Livingston(David M) Nat Cell Biol 2004-11-09

...BARD1 in vivo or in vitro and exhibits unique nuclear immunostaining. Unlike BRCA1FL (or p220), BRCA1-IRIS also co-immun...

BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S a...

Fabbro(Megan),Savage(Kienan),Hobson(Karen)... J Biol Chem 2004-09-21

...BARD1, is also implicated in the DNA damage response, and recent reports indicate that BRCA1 and BARD1 co-operate in thi...

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.

Starita(Lea M),Machida(Yuka),Sankaran(Sati... Mol Cell Biol 2004-11-01

...BARD1, ubiquitinate centrosome proteins. Results showed that centrosome components, including gamma-tubulin, are ubiquit...

BRCA1-independent ubiquitination of FANCD2.

Vandenberg(Cassandra J),Gergely(Fanni),Ong... Mol Cell 2003-09-05

...BARD1 complex, together with E1 and UbcH5a, is sufficient to reconstitute the monoubiquitination of FANCD2 in vitro. Alt...

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconve...

Wu-Baer(Foon),Lagrazon(Karen),Yuan(Wei),Ba... J Biol Chem 2003-11-12

The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and the resulting complex functions as an E3 ubiq...

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