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TP53 BRCA1 CRISPR single-cell cancer

Cockbain(Julian),Sterckx(Sigrid) Pharm Pat Anal 2014-06-17

...BRCA1/2 genes for breast and ovarian cancer. On appeal, the decision was almost entirely overturned. However, in March 2...

Stead(Lucy F),Egan(Philip),Devery(Aoife),Con… PLoS One 2014-08-18

...BRCA1 germline polymorphisms and reduced transcription of a potentially endogenous PARP2 inhibitor. Functional assays we...

Xie(Chengzhi),Drenberg(Christina),Edwards(Ho… PLoS One 2014-08-18

...BRCA1, CHK1, and RAD51 in AML cells in a dose-dependent manner. Further, panobinostat significantly increased cytarabine...

Pennington(Kathryn P),Walsh(Tom),Harrell(Mar… Clin Cancer Res 2014-10-06

Hallmarks of germline BRCA1/2-associated ovarian carcinomas include chemosensitivity and improved survival. The therapeu...

Watanabe(Sugiko),Watanabe(Kenji),Akimov(Vyac… Nat Struct Mol Biol 2014-02-24

...BRCA1 complex. We report that human demethylase JMJD1C regulates the RAP80-BRCA1 branch of this DNA-damage response (DDR...

Kohn(E C),Romano(S),Lee(J-M) Ann Oncol 2014-07-02

...BRCA1 or 2 have been validated as the first new predictive and prognostic biomarker of the high-grade serous ovarian can...

Abdel-Fatah(Tarek M A),Albarakati(Nada),Bowe… Breast Cancer Res Treat 2014-07-18

...BRCA1 (p < 0.0001), ATM (p < 0.0001) and XRCC1 (p < 0.0001). Low p27 (p < 0.0001), low p21 (p = 0.023), mutant p53 (p = ...

Casadio(Valentina),Molinari(Chiara),Calistri… J Exp Clin Cancer Res 2014-09-26

...BRCA1, CASP8, CDKN1B, PTEN, BRCA2, CD44, RASSF1, DAPK1, FHIT, VHL, ESR1, TP73, IGSF4, GSTP1 and CDH13) in primary lesion...

Gilardini Montani(Maria Saveria),Prodosmo(An… J Exp Clin Cancer Res 2014-09-26

Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP...

Lindner(Robert),Sullivan(Catherine),Offor(On… PLoS One 2014-07-07

...BRCA1 deficiency in this cohort. Using signatures derived from the meta-analysis of TNBC gene expression carried out by ...

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