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Development of synthetic lethality anticancer therapeutics.

Fang(Bingliang) J Med Chem 2014-12-18

...BRCA1- and BRCA2-mutant cancers, checkpoint inhibitors for p53 mutant cancers, and small molecule agents targeting RAS g...

Estrogen signaling and the DNA damage response in hormone dependent breast canc…

Caldon(C Elizabeth) Front Oncol 2014-06-24

...BRCA1, and p53 and the feedback on estrogen receptor signaling from these proteins. We put forward the hypothesis that e...

Phase I/Ib study of olaparib and carboplatin in BRCA1 or BRCA2 mutation-associa…

Lee(Jung-Min),Hays(John L),Annunziata(Christ… J Natl Cancer Inst 2014-07-07

...BRCA1 or BRCA2 mutation carriers (gBRCAm). We hypothesized addition of olaparib to carboplatin can be administered safel...

Strong and Sustained Response to Treatment with Carboplatin plus Nab-Paclitaxel…

Shakir(Abdur R) Case Rep Oncol 2014-05-21

Our case describes a 51-year-old female, diagnosed in April 2008 with a triple-negative, BRCA1-positive, infiltrating du...

The Importance of Multidisciplinary Approach in Early Detection of BAP1 Tumor P…

Battaglia(Angelo) Clin Med Insights Oncol 2014-06-24

...BRCA1-associated protein-1) mutations are involved into a novel specific cancer syndrome and strictly associated with a ...

Trabectedin mechanism of action: what's new?

D'Incalci(Maurizio) Future Oncol 2014-06-30

...BRCA1/2). Trabectedin also has potent immunomodulatory effects, being selectively cytotoxic against monocytes and tumor-...

Ki-67 and p53 expression of the fallopian tube mucosa in breast cancer patients…

Anton(Alina),Schott(Sarah),Kaip(Gisela),Rath… Arch Gynecol Obstet 2014-10-06

...BRCA1-related ovarian cancer. To investigate if Ki-67 or p53 is altered in BRCA1 mutation carriers, we have studied the ...

The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-c…

Bonanno(Laura),Costa(Carlota),Majem(Margarit… Oncotarget 2014-07-22

...BRCA1. The mRNA expression of BRCA1, MDC1, CASPASE3, UBC13, RNF8, 53BP1, PIAS4, UBC9 and MMSET was analyzed by real-time...

BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity a…

Jacot(William),Thezenas(Simon),Senal(Romain)… BMC Cancer 2014-06-23

...BRCA1 promoter methylation and 53BP1 expression in tumours without known BRCA1 mutation has not yet been carried out.,We...

[Multiple primary malignancies in BRCA1 mutation carriers--two clinical cases].

Badora(Agnieszka),Kaleta(Beata),Nowara(Elzbi… Ginekol Pol 2014-01-09

Mutations of BRCA1 and BRCA2 genes account for the majority of hereditary breast and ovarian cancers. So far; risk-reduc...

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