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TP53 BRCA1 CRISPR single-cell cancer

Cortesi(L),Razzaboni(E),Toss(A),De Matteis(E… Ann Oncol 2014-08-11

...BRCA1/2 mutation carriers by up to 95%, but the Italian attitude towards this procedure is reluctant.,This is an observa...

Yu(Chen),Liu(Shen-Lin),Qi(Ming-Hao),Zou(Xi) Mol Med Rep 2014-08-26

...BRCA1) and topoisomerase 1 (TOPO1), all in HT-29 and LoVo cells, with or without the addition of cinnamaldehyde, was exa...

Matthews(Lindsay A),Selvaratnam(Rajeevan),Jo… J Biol Chem 2014-04-10

...BRCA1 C-terminal (BRCT) domains are overrepresented in DNA damage and replication stress response proteins. They functio...

Al Abo(Muthana),Dejsuphong(Donniphat),Hirota… Cancer Res 2014-04-15

BRCA1, BRCA2, and PALB2 are key players in cellular tolerance to chemotherapeutic agents, including camptothecin, cispla...

Evans(D Gareth R),Ingham(Sarah L),Buchan(Iai… Cancer Epidemiol Biomarkers P… 2014-10-02

To establish, if among unaffected noncarrier relatives in a family with an established BRCA1/2 mutation, there is an inc...

Brohet(Richard M),Velthuizen(Maria E),Hogerv… J Med Genet 2014-09-08

...BRCA1 and 6% (95% CI 2 to 11%) for BRCA2 mutation carriers. In BRCA1 families, breast cancer relative risk (RR) increase...

Kohn(E C),Romano(S),Lee(J-M) Ann Oncol 2014-07-02

...BRCA1 or 2 have been validated as the first new predictive and prognostic biomarker of the high-grade serous ovarian can...

Birkbak(Nicolai Juul),Kochupurakkal(Bose),Iz… PLoS One 2014-07-25

...BRCA1 or BRCA2. The significance of these genome-wide mutations is unknown. We hypothesize genome-wide mutation burden m...

Deng(Hui),Li(Fulun),Li(Hong),Deng(Yu),Liu(Ji… J Invest Dermatol 2014-06-17

...Brca1, and E-cadherin, were downregulated in K5.CtBP1 skin. Surprisingly, K5.CtBP1 pups also exhibited a hair loss pheno...

van Driel(Catheleine M),Eltahir(Yassir),de V… Maturitas 2014-10-14

Strategies in case of high risk of breast cancer in BRCA1/2 mutation carriers are either intensive breast cancer screeni...

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