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Risk factors for ovarian cancers with and without microsatellite instability.

Segev(Yakir),Pal(Tuya),Rosen(Barry),McLaughl… Int J Gynecol Cancer 2014-02-18

...BRCA1 and BRCA2 mutation status, past oral contraceptive use, and tubal ligation. Similarly, we compared the distributio...

Breast cancer genes: beyond BRCA1 and BRCA2.

Filippini(Sandra E),Vega(Ana) Front Biosci (Landmark Ed) 2014-01-24

...BRCA1, BRCA2, PTEN and TP53, that are responsible for inherited syndromes. Moreover, a combination of family-based and p...

Poly(ADP-ribose) polymerase inhibitors as cancer therapy.

Hilton(John F),Hadfield(Matthew J),Tran(Minh… Front Biosci (Landmark Ed) 2014-01-24

...BRCA1 and BRCA2 mutations) by forcing NHEJ repair. Known as synthetic lethality, the use of NHEJ in these tumors generat...

The role of BRCA1 and BRCA2 in prostate cancer.

Li(Dan),Kumaraswamy(Easwari),Harlan-Williams… Front Biosci (Landmark Ed) 2014-01-24

...BRCA1 (breast cancer 1, early onset) and BRCA2. In this review, we are mainly focusing on the contribution of BRCA1/2 se...

Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 …

Ingle(James N),Liu(Mohan),Wickerham(D Lawren… Cancer Discov 2014-03-21

...BRCA1 expression, in both cases with SNP-dependent variation in induction. ZNF423 appeared to be an estrogen-inducible B...

Spinophilin loss correlates with poor patient prognosis in advanced stages of c…

Estevez-Garcia(Purificacion),Lopez-Calderero… Clin Cancer Res 2014-02-05

...Brca1, NM23, prohibitin, and spinophilin (Spn, PPP1R9B, neurabin II). The scaffold protein Spn is one of the regulatory ...

Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib fo…

Ihnen(Maike),zu Eulenburg(Christine),Kolarov… Mol Cancer Ther 2014-02-24

...BRCA1/2, baseline gene expression signatures, copy number variations of selected genes, PTEN status, and sensitivity to ...

BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells b…

May(Taymaa),Yang(Junzheng),Shoni(Melina),Liu… Neoplasia 2014-01-06

...BRCA1 promoter-regulated luciferase construct indicated that the CtBP2 complex binds the BRCA1 promoter and represses BR...

Pervasive sequence patents cover the entire human genome.

Rosenfeld(Jeffrey A),Mason(Christopher E) Genome Med 2014-05-20

...BRCA1 has 15mers matching at least 689 other genes. Longer sequences (1,000 bp) still showed extensive cross-gene matche...

BRCA1 regulates microtubule dynamics and taxane-induced apoptotic cell signalin…

Sung(M),Giannakakou(P) Oncogene 2014-05-15

...BRCA1, is a tumor-suppressor gene, whose expression has been correlated with taxane sensitivity in many solid tumors inc...

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