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Genetic analysis identifies putative tumor suppressor sites at 2q35-q36.1 and...

Narayan(Gopeshwar),Pulido(Hugo Arias),Koul... Oncogene 2003-06-26

...BARD1, XRCC5, or PPP1R7 genes mapped to the deleted regions. However, we did find evidence of downregulated gene express...

Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, resul...

McCarthy(Ellen E),Celebi(Julide T),Baer(Ri... Mol Cell Biol 2003-08-14

...BARD1. To explore the genetic relationship between BRCA1 and BARD1, we have examined the phenotype of Bard1-null mice. T...

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-li...

Brzovic(Peter S),Keeffe(Jennifer R),Nishik... Proc Natl Acad Sci U S A 2003-07-01

...BARD1 to form a RINGRING heterodimer. The BRCA1BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity su...

3rd Geneva aging workshop 2002: cancer, apoptosis and aging.

Irminger-Finger(Irmgard) Biochim Biophys Acta 2003-07-15

...BARD1. The functions of telomere shortening and telomerase, extra cellular matrix, or epigenetic changes were presented ...

Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction ...

Xia(Yan),Pao(Gerald M),Chen(Hong-Wu),Verma... J Biol Chem 2003-04-30

...BARD1 depends on direct interaction between the two proteins. Using K48A and K63A Ub mutants, we found that BARD1 stimul...

Control of biochemical reactions through supramolecular RING domain self-asse...

Kentsis(Alex),Gordon(Ronald E),Borden(Kath... Proc Natl Acad Sci U S A 2003-01-14

...BARD1), self-assemble into supramolecular structures in vitro that resemble those they form in cells. RING bodies form p...

BARD1 participates with BRCA1 in homology-directed repair of chromosome break...

Westermark(Ulrica K),Reyngold(Marsha),Olsh... Mol Cell Biol 2003-12-04

...BARD1. We report that expression of truncated mouse or human BARD1 peptides capable of interacting with Brca1 results in...

Mutational analysis of BARD1 in familial breast cancer patients in Japan.

Ishitobi(Makoto),Miyoshi(Yasuo),Hasegawa(S... Cancer Lett 2003-11-12

...BARD1, it is speculated that BARD1 mutations might affect the function of BRCA1, contributing to breast carcinogenesis. ...

Germline mutations of the BRCA1-associated ring domain (BARD1) gene in breast...

Ghimenti(Chiara),Sensi(Elisa),Presciuttini... Genes Chromosomes Cancer 2002-03-01

...BARD1 germline mutations in hereditary breast and breast/ovarian cancer patients. We analyzed the BARD1 gene in 40 famil...

Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene...

Spahn(Laura),Petermann(Robert),Siligan(Chr... Cancer Res 2002-09-25

...BARD1, a putative tumor suppressor, in vitro and in vivo. Because BARD1 associates via its NH2-terminal RING domain with...

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