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MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization o…

Zhang(Fan),Bick(Gregory),Park(Jung-Young),An… J Cell Sci 2014-01-29

...BRCA1, with the BRCT repeats that are present in, and which localize, BRCA1. Our results yield important insights into t...

BRCA1 and BRCA2 mutations in breast cancer patients from Venezuela.

Lara(Karlena),Consigliere(Nigmet),Pérez(Jorg… Biol Res 2014-01-07

...BRCA1 and BRCA2, respectively. Four pathogenic mutations were found in BRCA1, one is a novel mutation (c.951_952insA), w...

CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).

Choi(H-H),Choi(H-K),Jung(S Y),Hyle(J),Kim(B-… Oncogene 2014-03-03

...Brca1. In addition, CHK2 is thought to be a multi-organ cancer susceptibility gene. In this study, we used a tandem affi...

[Analysis of gene expression data regulated by clock-genes: methodological appr…

Vuillaume(M-L),Kwiatkowski(F),Uhrhammer(N),B… Pathol Biol (Paris) 2014-06-10

...BRCA1 was highly correlated to the period gene Per1; our correction methodology enabled us to recover genes coding for B...

Correlation between BRCA1 expression and clinicopathological factors including …

Gachechiladze(Mariam),Uberall(Ivo),Kolek(Vit… Biomed Pap Med Fac Univ Palac… 2014-03-12

...BRCA1 N-terminal and S1524 antibody against the phosphorylated form of BRCA1 protein at ser1524 (Abcam). Patients with I...

Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxali…

Mori(Ryutaro),Yoshida(Kazuhiro),Tanahashi(To… Gastric Cancer 2014-02-19

...BRCA1 is required for DNA double-strand break (DSB) repair. FANCJ also functions in interstrand crosslinks (ICLs) repair...

Understanding the needs of women considering risk-reducing salpingo-oophorectom…

Cherry(Carol),Ropka(Mary),Lyle(Jennifer),Nap… Cancer Nurs 2014-04-07

...BRCA1/2 genes, women with a deleterious mutation are recommended to undergo risk-reducing salpingo-oophorectomy at age 3...

The role of asynapsis in human spermatocyte failure.

Sciurano(R B),Rahn(M I),Rey-Valzacchi(G),Coc… Int J Androl 2014-07-21

...BRCA1 and retained RAD51 foci. The variant histone γ-H2AX is located on the chromatin domains of the asynaptic regions a...

Much more than a gene: hereditary breast and ovarian cancer, reproductive choic…

Dekeuwer(Catherine),Bateman(Simone) Med Health Care Philos 2014-02-26

...BRCA1 or the BRCA2 gene, associated with a high risk of breast and ovarian cancer, make their reproductive decisions. Us...

Role of polycomb group protein cbx2/m33 in meiosis onset and maintenance of chr…

Baumann(Claudia),De La Fuente(Rabindranath) Genes (Basel) 2014-04-08

...BRCA1, co-localized with fully synapsed chromosome axes in the majority of Cbx2((-/-)) oocytes. These results provide no...

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