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DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.

Santos(Margarida A),Faryabi(Robert B),Ergen(… Nature 2014-10-23

...BRCA1 sensitizes transformed cells to differentiation, suggesting that myeloid differentiation is promoted by loss of ge...

A BRCA1-mutation associated DNA methylation signature in blood cells predicts s…

Anjum(Shahzia),Fourkala(Evangelia-Ourania),Z… Genome Med 2014-07-28

...BRCA1 mutation carriers is able to predict non-hereditary breast cancer.,In a case/control setting (72 BRCA1 mutation ca...

Meiotic prophase I defects in an oligospermic man with Wolf-Hirschhorn syndrome…

Yao(Qi),Wang(Liu),Yao(Bing),Gao(Hongliu),Li(… Mol Cytogenet 2014-07-24

...BRCA1) in a testicular biopsy were examined by fluorescence immunostaining. In the oligospermia patient, 35.4% of sperma...

Lack of BAP1 protein expression in uveal melanoma is associated with increased …

Kalirai(H),Dodson(A),Faqir(S),Damato(B E),Co… Br J Cancer 2014-11-17

...BRCA1-associated protein 1 (BAP1) expression in uveal melanoma (UM) is associated with metastatic progression and reduce...

Rapid evolution of BRCA1 and BRCA2 in humans and other primates.

Lou(Dianne I),McBee(Ross M),Le(Uyen Q),Stone… BMC Evol Biol 2014-10-15

...BRCA1, we analyzed complete BRCA1 gene sequences from 23 primate species. We show that specific amino acid sites have ex...

Genetic variations of BRCA1 and BRCA2 genes in dogs with mammary tumours.

Enginler(S O),Akış(I),Toydemir(T S F),Oztaba… Vet Res Commun 2014-07-08

...BRCA1 and BRCA2 are the most important genes significantly associated with mammary tumours. The aim of this study was to...

Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cell…

Xu(Hong),Xian(Jian),Vire(Emmanuelle),McKinne… J Pathol 2014-12-09

...BRCA1 or RAD51 also exhibited over-expression of IFN-related genes. Transcriptional activity of the IFN-stimulated respo...

Comprehensive BRCA1 and BRCA2 mutational profile in Lithuania.

Janavičius(Ramūnas),Rudaitis(Vilius),Mickys(… Cancer Genet 2014-10-07

...BRCA1 gene. In all, 10 novel BRCA1/2 mutations were found. Nine different recurrent BRCA1 mutations and two recurrent BR...

Overall survival and clinical characteristics of pancreatic cancer in BRCA muta…

Golan(T),Kanji(Z S),Epelbaum(R),Devaud(N),Da… Br J Cancer 2014-11-04

...BRCA1/2 mutation carriers with pancreatic cancer may have distinct biologic outcomes.,Patients with BRCA1/2-associated p...

Histological groups of human postpubertal testicular germ cell tumours harbour …

Vladušić(Tomislav),Hrašćan(Reno),Krušlin(Bož… Anticancer Res 2014-11-11

...BRCA1; BCL2-Associated X Protein, BAX; ATP-Binding Cassette, Sub-Family G (WHITE), Member 2, ABCG2. Genetic alterations,...

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