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Prostate cancer screening characteristics in men with BRCA1/2 mutations attendi…

Walker(Richard),Louis(Alyssa),Berlin(Alejand… Can Urol Assoc J 2014-12-08

...BRCA1/2 genes have been associated with prostate cancer risk and prognosis. We describe the prostate cancer screening ch...

Saturation editing of genomic regions by multiplex homology-directed repair.

Findlay(Gregory M),Boyle(Evan A),Hause(Ronal… Nature 2014-09-24

...BRCA1, we replace a six-base-pair (bp) genomic region with all possible hexamers, or the full exon with all possible sin...

PALB2: the hub of a network of tumor suppressors involved in DNA damage respons…

Park(Jung-Young),Zhang(Fan),Andreassen(Paul … Biochim Biophys Acta 2014-11-10

...BRCA1 tumor suppressors. Next, PALB2 interacts with BRCA2, which is a tumor suppressor, and with the RAD51 recombinase. ...

Characteristics of BRCA1/2 Mutation-Positive Breast Cancers in Korea: A Compari…

Yu(Jong-Han),Lee(Jong Won),Son(Byung Ho),Kim… J Breast Cancer 2014-07-11

...BRCA1 (BRCA1 group) and BRCA2 (BRCA2 group) mutations.,We retrospectively reviewed the medical records of patients with ...

Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian ca…

Hartley(Taila),Cavallone(Luca),Sabbaghian(Ne… Hered Cancer Clin Pract 2014-09-16

...BRCA1/2 -negative breast and/or ovarian cancer families to a) assess the contribution of PALB2 mutations in this series ...

The prevalence of BRCA1/2 mutations of triple-negative breast cancer patients i…

Li(Yong Tao),Ni(Duo),Yang(Liang),Zhao(Qian),… Eur J Med Res 2014-10-16

The screening of BRCA1 and BRCA2 mutations is now an established component of risk evaluation and management of familial...

Radium-223 dichloride bone-targeted alpha particle therapy for hormone-refracto…

Takalkar(Amol),Adams(Scott),Subbiah(Vivek) Exp Hematol Oncol 2014-09-22

...BRCA1-negative, BRCA2-negative, PIK3CA mutation (p.His1047Arg) positive presented with diffuse bony metastases and bone ...

Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH…

Peng(Min),Xie(Jenny),Ucher(Anna),Stavnezer(J… EMBO J 2014-09-30

Several proteins in the BRCA-Fanconi anemia (FA) pathway, such as FANCJ, BRCA1, and FANCD2, interact with mismatch repai...

Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) …

Ström(Cecilia E),Helleday(Thomas) Biomolecules 2014-06-27

...BRCA1 or BRCA2 genes a new and in many cases effective option for disease control. There is potentially a large patient ...

Host Cell Reactivation and Transcriptional Activation of Carboplatin-Modified B…

Ratanaphan(Adisorn),Canyuk(Bhutorn) Breast Cancer (Auckl) 2014-03-28

...BRCA1 C-terminal domain) acts as a strong transcriptional activator. BRCA1 damaged by carboplatin treatment may lead to ...

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