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Is there a link between ovarian cancer and tooth agenesis?

Bonds(John),Pollan-White(Sarah),Xiang(Lilin)… Eur J Med Genet 2014-12-09

...BRCA1 genes were selected for sequence analysis as they may cause tooth agenesis, are expressed in the female reproducti...

Role of BRCA1 in brain development.

Pao(Gerald M),Zhu(Quan),Perez-Garcia(Carlos … Proc Natl Acad Sci U S A 2014-06-02

...BRCA1 loss to a greater extent than p53. Our results suggest distinct apoptotic and centrosomal functions of BRCA1 in ne...

TP53 p.R337H prevalence in a series of Brazilian hereditary breast cancer famil…

Cury(Nathalia M),Ferraz(Victor Ef),Silva(Wil… Hered Cancer Clin Pract 2014-03-20

...BRCA1 and BRCA2 genes and is characterized by breast adenocarcinoma and/or epithelial ovarian carcinoma. LFS is associat...

Underestimation of risk of a BRCA1 or BRCA2 mutation in women with high-grade s…

Daniels(Molly S),Babb(Sheri A),King(Robin H)… J Clin Oncol 2014-07-23

Identification of the 10% to 15% of patients with ovarian cancer who have germline BRCA1 or BRCA2 mutations is important...

BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instabilit…

Savage(Kienan I),Matchett(Kyle B),Barros(Eli… Cancer Res 2014-08-07

...BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stabili...

Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting …

Konstantinopoulos(Panagiotis A),Wilson(Andre… Gynecol Oncol 2014-07-16

...BRCA1null and UWB1.289+BRCA1 wild-type) were treated with saline vehicle, olaparib, SAHA or olaparib/SAHA. Sulforhodamin...

Clinical interpretation and implications of whole-genome sequencing.

Dewey(Frederick E),Grove(Megan E),Pan(Cuipin… JAMA 2014-03-31

...BRCA1 gene implicated in hereditary breast and ovarian cancer. Physician review of sequencing findings prompted consider...

The clinical utility of genetic testing in breast cancer kindreds: a prospectiv…

Møller(Pål),Stormorken(Astrid),Holmen(Marit … Breast Cancer Res Treat 2014-11-18

...BRCA1/2 mutation. According to family history, the optimal available member(s) of each breast cancer kindred attending o...

Glucocorticoid receptor repression mediated by BRCA1 inactivation in ovarian ca…

Fang(Yuan-Yuan),Li(Da),Cao(Chen),Li(Chun-Yan… BMC Cancer 2014-11-06

...BRCA1-mutated or not, 23 pairs of BRCA2-mutated or not, and 22 pairs with hypermethylated BRCA1 promoter or not). BRCA1 ...

Polymorphisms in phase I and phase II genes and breast cancer risk and relation…

Ghisari(Mandana),Eiberg(Hans),Long(Manhai),B… Environ Health 2014-10-09

...BRCA1 was as expected higher in cases than in controls.,The BRCA1 founder mutation and polymorphisms in CYP1A1 (Val) and...

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