The BRCA1 and BRCA2 genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancer...
...BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC are the most important BRCA1 an...
...BRCA1 C-terminal (BRCT) domains are overrepresented in DNA damage and replication stress response proteins. They functio...
BRCA1, BRCA2, and PALB2 are key players in cellular tolerance to chemotherapeutic agents, including camptothecin, cispla...
To establish, if among unaffected noncarrier relatives in a family with an established BRCA1/2 mutation, there is an inc...
...BRCA1 and 6% (95% CI 2 to 11%) for BRCA2 mutation carriers. In BRCA1 families, breast cancer relative risk (RR) increase...
...BRCA1/BRCA2 testing which has become part of clinical practice for more than a decade. Currently predictive BRCA1/BRCA2 ...
...Brca1 and 12 members of the Brca1 associated genome surveillance complex are also downregulated. Activation of caspase 3...
We analyzed wild-type (WT) and four sequence variants of the BRCA1 promoter region-found in patients selected for heredi...
...BRCA1 mRNA tumour content also failed to predict platinum resistance in 287 stage IV NSCLC patients included in a phase ...
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