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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breas...

Hashizume(R),Fukuda(M),Maeda(I),Nishikawa(... J Biol Chem 2001-06-28

...BARD1 have very low ubiquitin ligase activities in vitro, BRCA1 combined with BARD1 exhibits dramatically higher activit...

The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and t...

Kleiman(F E),Manley(J L) Cell 2001-04-05

...BARD1, and BRCA1 protein levels, increased amounts of a CstF/BARD1/BRCA1 complex were detected. Supporting the physiolog...

Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1.

Wang(Q),Zhang(H),Guerrette(S),Chen(J),Mazu... Oncogene 2001-08-23

...BARD1, another BRCA1-interacting protein, was also found to interact with hMSH2. In addition, BRCA1 was found to associa...

BRCA1 RING domain cancer-predisposing mutations. Structural consequences and ...

Brzovic(P S),Meza(J E),King(M C),Klevit(R ... J Biol Chem 2001-12-07

...BARD1 RING domain. Each of the BRCA1 Site II mutants still interact and form a stable heterodimer with BARD1. Limited pr...

Redistribution of BRCA1 among four different protein complexes following repl...

Chiba(N),Parvin(J D) J Biol Chem 2001-12-04

...BARD1. These data suggest that BRCA1 participates in multiple cellular processes by multiple protein complexes and that ...

Functional communication between endogenous BRCA1 and its partner, BARD1, dur...

Joukov(V),Chen(J),Fox(E A),Green(J B),Livi... Proc Natl Acad Sci U S A 2001-12-28

...BARD1 function supports the view that BARD1/BRCA1 heterodimers play a major role in breast and ovarian cancer suppressio...

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

Brzovic(P S),Rajagopal(P),Hoyt(D W),King(M... Nat Struct Biol 2001-10-18

...BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations foun...

Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in bre...

Yoshikawa(K),Ogawa(T),Baer(R),Hemmi(H),Hon... Int J Cancer 2000-09-26

...BARD1 (BRCA1-associated RING domain 1) and p53, all of which are involved in DNA repair. We have analyzed the expression...

Functional characterization of BRCA1 and BRCA2: clues from their interacting ...

Sharan(S K),Bradley(A) J Mammary Gland Biol Neoplasia 2000-06-02

...BARD1, importin-alpha, BIPs, RNA polymerase II holoenzyme, BRAP2 etc. Recently, mutations suggesting a role as a tumor s...

Localization of BRCA1 protein at the cellular level.

De Potter(C R),Coene(E D),Schelfhout(V R) J Mammary Gland Biol Neoplasia 2000-06-02

...BARD1, involved in transcription regulation and participating in DNA replication checkpoints. However, many authors have...

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