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Doraczynska-Kowalik(A),Matkowski(R),Michal... J Cancer Res Clin Oncol 2026-06-23

BRCA1 and BRCA2 are key susceptibility genes in hereditary breast and ovarian cancer (HBOC), with mutational status guid...

Schnaiter(S),Santer(FR),Csanaky(KA),Jensen... Am J Hum Genet 2026-07-02

...BRCA1 or BRCA2 wild type [BRCAwt]), 91.0% of BRCApv and 30.0% of BRCAwt tumors were HRD-GIShigh. The LR for a BRCA1 or B...

Metcalfe(K),Narod(SA),Poll(A),Hoey(C),Warn... Br J Cancer 2026-06-23

...BRCA1, BRCA2, BRIP1, CDH1, CHEK2, PALB2, PTEN, STK11, RAD51D, RAD51C, EPCAM, MLH1, MSH2, MSH6, and PMS2). Prevalence of ...

Solanes-Cabús(A),Castillo-Manzano(C),Rofes... Eur J Hum Genet 2026-06-23

We hypothesized that the BRCA1 c.68_69del variant is highly prevalent among individuals with Roma ancestry from Spain du...

Senter(L),Hovick(S),Notestine(R),Norden(L)... Cancer Prev Res (Phila) 2026-06-24

Individuals with germline BRCA1 or BRCA2 pathogenic variants (PVs) may struggle with risk management decision-making. Ad...

Herold(N),Engel(C),Speiser(D),Ripperger(T)... Eur J Cancer 2026-08-26

...BRCA1 and BRCA2 SH carriers were less likely to present with higher disease severity than BRCA1/BRCA2 DH carriers (BRCA1...

Chen(H),Yang(W),Ying(Z),Li(A),Yang(X),Liu(... Sci Rep 2026-06-25

...BRCA1, BRCA2, and RAD51) in BC cells after MELK silencing. Additionally, WB was used to examine the impact of Clofibrate...

Zuo(J),Wang(K),Cui(Z),Li(Q),Cheng(X),Zheng... Chin Med J (Engl) 2026-06-24

...BRCA1/2 wild-type and HRD-proficient subgroups, respectively. PFS rates at 36 months were 67.5% in the BRCA1/2-mutated, ...

Fadebi(OO),Alabi(BA),Khanyile(R),Dlamini(Z... Epigenomes 2026-06-01

...BRCA1 axis in response to the PARP inhibitor, Olaparib. Our results demonstrate that Olaparib induces selective cytotoxi...

Torretto(GC),Martin(MD),Islam(K),Archer(NE... Curr Oncol 2026-06-11

...BRCA1 variants. In silico tools scored known consequence variants within a specific region of BRCA1. The Molecular Featu...