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TP53 BRCA1 CRISPR single-cell cancer

Liu(J),Chu(F),Yao(L),Sun(J),Chen(J),Zhang(... Breast Cancer Res Treat 2026-01-06

...BRCA1 PVs, 433 carried BRCA2 PVs, and 10,495 were non-carriers. After a median follow-up of 8.4 years, 10.9% of BRCA1 ca...

Kang(DY),Chi(WJ),Cho(J),Jang(KJ) Sci Rep 2026-01-07

...BRCA1, and p53 and normalized cell cycle regulation by modulating the expression of CDK4, Cyclin D1/E, and p21/p27. Cell...

Darnold(JS),Jonkers(J) Nat Genet 2026-07-00

...BRCA1 and BRCA2 (hereafter referred to as BRCA1/2) hereditary breast and ovarian cancer genes three decades ago, genetic...

Arora(M),Yaseen(YS),Mahmood(AAR),Sangi(SMA... BMC Pharmacol Toxicol 2026-01-06

...BRCA1-associated tumor progression is involved.

Deng(J),Yang(B),Zhao(Z) Medicine (Baltimore) 2026-01-02

...BRCA1, CD36, ENO3, INHBB, PHLDA2) model showed robust predictive efficacy (1-, 3-, 5-year OS area under the curve: 0.889...

Zhou(J),Zhou(XA),Hu(L),Ma(Y),Zhan(J),Xu(Z)... Elife 2026-01-07

...BRCA1-deficient breast cancers. However, the reason why LPs are prone to transform with BRCA1 deficiency has not been el...

Park(K),Kim(JC),Kim(SH),Kim(J),Kim(HS),Cho... Turk J Surg 2026-03-05

...BRCA1 mutation carriers are at increased risk of developing early-onset disease. While bariatric surgery reduces the inc...

Santamariña(M),Fuentes-Ríos(O),Blanco-Pére... Clin Chem 2026-02-03

Germline loss-of-function variants in BRCA1 and BRCA2 are established drivers of hereditary breast and ovarian cancer, o...

Lencz(T),Bhattacharyya(U),Klausner(L),John... NPJ Genom Med 2026-01-07

...BRCA1, BRCA2, and PALB2 resulted in a risk distribution that was essentially disjoint from the non-carriers, regardless ...

van Genugten(JHLT),Fennell(DA),Baas(P) Oncogene 2026-02-00

...BRCA1-associated protein 1 (BAP1) tumor suppressor gene. This alteration typically occurs as an early clonal event in me...

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