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Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer ri…

Weitzel(Jeffrey N),Clague(Jessica),Martir-Ne… J Clin Oncol 2013-05-14

...BRCA1, 65 BRCA2); 21 (11%) of 189 were large rearrangement mutations, of which 62% (13 of 21) were BRCA1 ex9-12del. Nine...

Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovari…

Wappenschmidt(Barbara),Becker(Alexandra A),H… PLoS One 2013-05-30

Screening for pathogenic mutations in breast and ovarian cancer genes such as BRCA1/2, CHEK2 and RAD51C is common practi...

The microRNA maturation regulator Drosha is an independent predictor of outcome…

Khoshnaw(Sarkawt M),Rakha(Emad A),Abdel-Fata… Breast Cancer Res Treat 2013-05-27

...BRCA1 and ER expression and with shorter BC specific survival (BCSS), disease free interval (DFI) and distant metastasis...

Association between BRIP1 (BACH1) polymorphisms and breast cancer risk: a meta-…

Pabalan(Noel),Jarjanazi(Hamdi),Ozcelik(Hilmi) Breast Cancer Res Treat 2013-07-25

...BRCA1 interacting protein 1 (BRIP1) gene and breast cancer prompted us to undertake a meta-analysis. Although investigat...

Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial a…

Jara(Lilian),Gonzalez-Hormazabal(Patricio),C… Breast Cancer Res Treat 2013-07-25

...BRCA1/2-negative Chilean BC cases and 802 controls. All the SNPs studied were significantly associated with increased BC...

Hereditary gynaecological malignancies: advances in screening and treatment.

Folkins(Ann K),Longacre(Teri A) Histopathology 2013-06-13

...BRCA1 and BRCA2 genes in ovarian cancer and the mismatch repair genes in endometrial carcinoma has revolutionized our ap...

Structure and functional analysis of the BRCT domain of translesion synthesis D…

Pryor(John M),Gakhar(Lokesh),Washington(M To… Biochemistry 2013-03-05

...BRCA1 C-terminal (BRCT) domain that is required for its function. The rev1-1 allele encodes a mutant form of Rev1 with a...

Role of conventional chemosensitivity test and tissue biomarker expression in p…

Arienti(Chiara),Tesei(Anna),Verdecchia(Giorg… Clin Colorectal Cancer 2013-11-04

...BRCA1, ERCC1, GSTP1, and XPD gene expression levels were determined by real-time reverse transcription polymerase chain ...

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression…

Chapman(J Ross),Barral(Patricia),Vannier(Jea… Mol Cell 2013-04-30

...BRCA1, and deletion of Rif1 suppresses toxic nonhomologous end joining (NHEJ) induced by PARP inhibition in Brca1-defici...

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP…

Escribano-Díaz(Cristina),Orthwein(Alexandre)… Mol Cell 2013-04-30

...BRCA1. 53BP1 stimulates nonhomologous end joining (NHEJ), whereas BRCA1 promotes end resection and homologous recombinat...

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