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Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gen…

Wark(Landon),Novak(David),Sabbaghian(Nelly),… Genes Chromosomes Cancer 2013-08-26

PALB2/FANCN is a BRCA1- and BRCA2-interacting Fanconi Anemia (FA) protein crucial for key BRCA2 genome caretaker functio...

Determination of molecular markers for BRCA1 and BRCA2 heterozygosity using gen…

Salmon(Asher Y),Salmon-Divon(Mali),Zahavi(Ta… Cancer Prev Res (Phila) 2013-07-19

...BRCA1 and BRCA2. We searched for genes that have the potential to distinguish healthy BRCA1 and BRCA2 mutation carriers ...

[Expression and clinical significance of BRCA1 in human esophageal squamous cel…

Yang(Yi-xuan),Xue(Li-yan),Dong(Li-jia),Fu(Mi… Zhonghua Zhong Liu Za Zhi 2013-08-12

...BRCA1 and lymph node metastasis. In the tumors with positive lymph nodes, strong positive expression of BRCA1 was found ...

Microenvironmental regulation of BRCA1 gene expression by c-Jun and Fra2 in pre…

Zhou(Lixin),Graves(Marcia),MacDonald(Gwen),C… Mol Cancer Res 2013-09-03

...BRCA1 mRNA and protein fell significantly and the transcriptional activation state of the BRCA1 promoter was suppressed....

Prophylactic mastectomy: an appraisal.

Zagouri(Flora),Chrysikos(Dimosthenis T),Serg… Am Surg 2013-03-18

...BRCA1 or BRCA2 mutation carriers. Prophylactic mastectomy includes the simple method and the subcutaneous method. Both m...

Reducing the risk of nipple necrosis: technical observations in 340 nipple-spar…

Stolier(Alan J),Levine(Edward A) Breast J 2013-09-20

...BRCA1/2 gene mutation. There were two flap losses and 14 hematomas. Complete nipple necrosis occurred in three cases (0....

BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer…

Grotsky(David A),Gonzalez-Suarez(Ignacio),No… J Cell Biol 2013-03-27

...BRCA1 deficiency and is associated with BRCA1-deficient and triple-negative breast cancers (TNBC) and with resistance to...

BRCA1-Ku80 protein interaction enhances end-joining fidelity of chromosomal dou…

Jiang(Guochun),Plo(Isabelle),Wang(Tong),Rahm… J Biol Chem 2013-05-30

...BRCA1, a tumor suppressor, enhances the fidelity of NHEJ-mediated DSB repair and prevents mutagenic deletional end-joini...

Role of 53BP1 oligomerization in regulating double-strand break repair.

Lottersberger(Francisca),Bothmer(Anne),Robbi… Proc Natl Acad Sci U S A 2013-04-09

...Brca1-deficient cells. The data therefore support two conclusions. First, the requirements for 53BP1 in mediating NHEJ a...

Genetic variants associated with breast cancer risk for Ashkenazi Jewish women …

Rinella(Erica S),Shao(Yongzhao),Yackowski(La… Hum Genet 2013-06-18

...BRCA1/2 mutations. This study incorporates three datasets in a GWAS analysis of women with Ashkenazi Jewish (AJ) homogen...

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