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Functional and structural analysis of C-terminal BRCA1 missense variants.

Quiles(Francisco),Fernández-Rodríguez(Juana)… PLoS One 2013-11-11

...BRCA1, while variants Q1409L, S1473P, E1586G and R1589H behave like wild-type BRCA1. In conclusion, our results suggest ...

DNA-bound platinum is the major determinant of cisplatin sensitivity in head an…

Martens-de Kemp(Sanne R),Dalm(Simone U),Wijn… PLoS One 2013-11-11

...BRCA1, BRCA2 and ERCC1).,Our findings suggest that the cisplatin-DNA adduct level is the most important determinant of c...

Cytochrome P450 2A13 enhances the sensitivity of human bronchial epithelial cel…

Yang(Xuejiao),Zhang(Zhan),Wang(Xichen),Wang(… Toxicol Appl Pharmacol 2013-10-18

...BRCA1, and H2AX, rather than the proteins related to DNA repair. These effects could be almost completely inhibited by 1...

Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expressio…

Kim(Jin Won),Cho(Hyun Jin),Kim(Miso),Lee(Kyu… Cancer Chemother Pharmacol 2013-08-01

...BRCA1 nuclear expression analysis by immunohistochemistry (IHC) on tissue microarrays using anti-BRCA1 antibody MS110, B...

Germline mutations in NF1 and BRCA1 in a family with neurofibromatosis type 1 a…

Campos(Berta),Balmaña(Judith),Gardenyes(Jose… Breast Cancer Res Treat 2013-12-30

...BRCA1/2 germline mutations. Mutation analyses identified a frameshift mutation in BRCA1 and a nonsense mutation in NF1. ...

Clinicopathological significance of KU70/KU80, a key DNA damage repair protein …

Alshareeda(Alaa T),Negm(Ola H),Albarakati(Na… Breast Cancer Res Treat 2013-12-30

...BRCA1-associated tumours and showed an inverse correlation with nuclear BRCA1 protein and aberrant cytoplasmic RAD51 exp...

BRCA1 is a negative modulator of the PRC2 complex.

Wang(Lan),Zeng(Xianzhuo),Chen(Shuai),Ding(Li… EMBO J 2013-08-09

...BRCA1 interacts with the Polycomb protein EZH2 in mouse embryonic stem (ES) and human breast cancer cells. The BRCA1-bin...

Dealing with the unexpected: consumer responses to direct-access BRCA mutation …

Francke(Uta),Dijamco(Cheri),Kiefer(Amy K),Er… PeerJ 2013-07-04

...BRCA1 and BRCA2 mutation-positive individuals in the 23andMe customer database who had chosen to view their BRCA reports...

The C-terminal region of Rad52 is essential for Rad52 nuclear and nucleolar loc…

Koike(Manabu),Yutoku(Yasutomo),Koike(Aki) Biochem Biophys Res Commun 2013-08-06

...BRCA1. Here, we show that the subcellular localization of EYFP-Rad52(1-418) changes dynamically during the cell cycle. I...

First evidence for the contribution of the genetic variations of BRCA1-interact…

Ma(X D),Cai(G Q),Zou(W),Huang(Y H),Zhang(J R… Gene 2013-08-05

...BRCA1-interacting protein 1), a DNA-dependent ATPase and a DNA helicase, is critical for BRCA-associated DNA damage repa...

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