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Association between a novel polymorphism (rs2046210) of the 6q25.1 locus and br…

Yang(Ziang),Shen(Juping),Cao(Zhigang),Wang(B… Breast Cancer Res Treat 2013-10-23

...BRCA1 mutation carriers and exhibited weaker association with the risk for BRCA2 mutation carriers. Substantial heteroge...

Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective an…

Mavaddat(Nasim),Peock(Susan),Frost(Debra),El… J Natl Cancer Inst 2013-08-05

Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of ...

Combination of protein coding and noncoding gene expression as a robust prognos…

Akagi(Ichiro),Okayama(Hirokazu),Schetter(Aar… Cancer Res 2013-09-04

...BRCA1, HIF1A, DLC1, and XPO1 were each significantly associated with prognosis in the Japan and US/Norway cohorts. A Cox...

BRCA1: a missing link in the Fanconi anemia/BRCA pathway.

D'Andrea(Alan D) Cancer Discov 2013-09-24

...BRCA1 alleles. These findings further implicate BRCA1 in the Fanconi anemia/BRCA pathway and have important implications...

Next-generation sequencing meets genetic diagnostics: development of a comprehe…

Feliubadaló(Lídia),Lopez-Doriga(Adriana),Cas… Eur J Hum Genet 2013-10-29

...BRCA1 and BRCA2. A NGS-based workflow was designed using BRCA MASTR kit amplicon libraries followed by GS Junior pyroseq...

SLUG silencing increases radiosensitivity of melanoma cells in vitro.

Arienti(Chiara),Tesei(Anna),Carloni(Silvia),… Cell Oncol (Dordr) 2013-09-16

...BRCA1, ERCC1, DNA-PK, PARP, MGMT, ATM and TGM2 were determined by real-time RT-PCR, and protein expression levels of SLU...

Biallelic deleterious BRCA1 mutations in a woman with early-onset ovarian cance…

Domchek(Susan M),Tang(Jiangbo),Stopfer(Jill)… Cancer Discov 2013-09-24

...BRCA1 mutations have not been confirmed, presumably because one wild-type BRCA1 allele is required during embryogenesis....

Long-term ovarian cancer survival associated with mutation in BRCA1 or BRCA2.

McLaughlin(John R),Rosen(Barry),Moody(Joel),… J Natl Cancer Inst 2013-03-01

...BRCA1 or BRCA2 mutation is better than expected. We sought to evaluate the impact of carrying a BRCA1 or BRCA2 mutation ...

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma.

Verhaak(Roel G W),Tamayo(Pablo),Yang(Ji-Yeon… J Clin Invest 2013-03-11

...BRCA1/BRCA2 mutation status, residual disease after surgery, and disease stage further optimized outcome classification....

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-de…

Smeenk(Godelieve),Wiegant(Wouter W),Marteijn… J Cell Sci 2013-11-19

...BRCA1 complex throughout DSB-flanking chromatin. This suggests that PARP regulates the spatial organization of the RNF16...

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