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Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcin…

Shakya(Reena),Gonda(Tamas),Quante(Michael),S… Cancer Res 2013-03-26

...Brca1 mice). In untreated tumors, we found globally decreased 5-methyl-cytosine (5-mC) in malignant epithelial cells and...

Does a role for selenium in DNA damage repair explain apparent controversies in…

Bera(Soumen),De Rosa(Viviana),Rachidi(Walid)… Mutagenesis 2013-08-16

...BRCA1 and Gadd45. An improved understanding of the mechanism of selenium's impact on DNA repair processes may help to re...

Low prevalence of SLX4 loss-of-function mutations in non-BRCA1/2 breast and/or …

de Garibay(Gorka Ruiz),Díaz(Avellaneda),Gavi… Eur J Hum Genet 2013-10-29

...BRCA1/BRCA2 multiple-case breast and/or ovarian cancer families (non-BRCA1/2 families) from Spain. We detected one unequ...

Activation of Evi1 inhibits cell cycle progression and differentiation of hemat…

Kustikova(O S),Schwarzer(A),Stahlhut(M),Brug… Leukemia 2013-07-19

...Brca1, Brca2, Rad51). Cell cycle analysis demonstrated EVI1's anti-proliferative effect to be strictly dose-dependent wi...

Molecular pathology of uveal melanoma.

Coupland(S E),Lake(S L),Zeschnigk(M),Damato(… Eye (Lond) 2013-06-03

...BRCA1-associated protein-1 (BAP1) inactivating mutations. Genetic testing of UM has enhanced prognostication, especially...

Genomic characterization of two large Alu-mediated rearrangements of the BRCA1 …

Peixoto(Ana),Pinheiro(Manuela),Massena(Lígia… J Hum Genet 2013-06-11

...BRCA1 gene. The first rearrangement harbored a 89,664-bp deletion comprising exon 7 of the BRCA1 gene to exon 11 of the ...

BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by select…

Wu(Lixian),Shao(Lijian),Li(Manna),Zheng(Juny… Radiat Res 2013-04-12

...Brca1 and Rad51 foci assays. The mechanisms by which BMS inhibits HR were examined by microarray analysis and quantitati...

Systematic tracking of dysregulated modules identifies novel genes in cancer.

Srihari(Sriganesh),Ragan(Mark A) Bioinformatics 2013-11-08

...BRCA1 and BRCA2 breast tumors showed specific differences even across the two sub-types and revealed novel genes involve...

Functional and structural analysis of C-terminal BRCA1 missense variants.

Quiles(Francisco),Fernández-Rodríguez(Juana)… PLoS One 2013-11-11

...BRCA1, while variants Q1409L, S1473P, E1586G and R1589H behave like wild-type BRCA1. In conclusion, our results suggest ...

DNA-bound platinum is the major determinant of cisplatin sensitivity in head an…

Martens-de Kemp(Sanne R),Dalm(Simone U),Wijn… PLoS One 2013-11-11

...BRCA1, BRCA2 and ERCC1).,Our findings suggest that the cisplatin-DNA adduct level is the most important determinant of c...

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