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BRCA1 is a key regulator of breast differentiation through activation of Notch …

Buckley(Niamh E),Nic An tSaoir(Caoimhe B),Bl… Nucleic Acids Res 2013-12-03

Here, we show for the first time, that the familial breast/ovarian cancer susceptibility gene BRCA1 activates the Notch ...

The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA doubl…

Sy(Shirley M H),Jiang(Jun),O(Wai Sum),Deng(Y… Nucleic Acids Res 2013-12-03

...BRCA1 and 53BP1 and compromised cell survival after ionizing radiation. We propose that USP34 promotes a feed-forward lo...

Deleterious BRCA1/2 mutation is an independent risk factor for carboplatin hype…

Moon(D H),Lee(J-M),Noonan(A M),Annunziata(C … Br J Cancer 2013-11-04

We tested the hypothesis that BRCA1/2 mutation carriers with ovarian cancer are at higher risk of carboplatin hypersensi...

Are physician recommendations for BRCA1/2 testing in patients with breast cance…

McCarthy(Anne Marie),Bristol(Mirar),Fredrick… Cancer 2013-12-03

...BRCA1/2 mutations.,Nearly 25% of the participants were classified as being at high risk of carrying a BRCA1/2 mutation b...

Medical mistrust influences black women's level of engagement in BRCA 1/2 genet…

Sheppard(Vanessa B),Mays(Darren),LaVeist(Tho… J Natl Med Assoc 2013-07-30

...BRCA1/2 genetic counseling and testing for managing hereditary breast and ovarian cancer risk; however, BRCA1/2 genetic ...

Breast cancer in women aged 25 years and younger.

Dimitrakakis(Constantine),Tsigginou(Alexandr… Obstet Gynecol 2013-09-17

...BRCA1 and BRCA2 mutations was performed in 12 of 28 young patients and mutations were found in 25% of them. Moreover, yo...

[Prophylactic surgery in common hereditary cancer syndromes].

Noguès(Catherine),Mouret-Fourme(Emmanuelle) Bull Acad Natl Med 2013-07-17

...BRCA1/BRCA2 mutation carriers. Bilateral prophylactic salpingo-oophorectomy is recommended for BRCA1/ BRCA2 carriers: wo...

Decisional outcomes of maternal disclosure of BRCA1/2 genetic test results to c…

Tercyak(Kenneth P),Mays(Darren),DeMarco(Tiff… Cancer Epidemiol Biomarkers P… 2013-11-06

Although BRCA1/2 genetic testing is discouraged in minors, mothers may disclose their own results to their children. Fac...

Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with …

Hawkes(Jason E),Campbell(Jennifer),Garvin(Da… Front Oncol 2013-07-05

...BRCA1-associated protein-1 (BAP1). Recently, germ-line mutations in BAP1, the gene encoding a tumor suppressing deubiqui...

Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetical…

Killick(Emma),Morgan(Richard),Launchbury(Fra… Sci Rep 2013-10-17

...BRCA1 and BRCA2 mutation carriers are at increased risk of clinically significant prostate cancer and may benefit from s...

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