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[Characteristics of selected clinical features in BRCA1 mutation carriers affec…

Menkiszak(Janusz),Chudecka-Głaz(Anita),Gronw… Ginekol Pol 2013-12-05

...BRCA1 gene mutation carriers previously treated for breast cancer.,206 carriers of one of the three most common BRCA1 ge...

Ovarian cancer stroma: pathophysiology and the roles in cancer development.

Furuya(Mitsuko) Cancers (Basel) 2013-11-11

...BRCA1 and BRCA2 have been well investigated. These genes are widely accepted as the predisposing factors that trigger ma...

The Clinical Significance of Unknown Sequence Variants in BRCA Genes.

Calò(Valentina),Bruno(Loredana),La Paglia(La… Cancers (Basel) 2013-11-27

Germline mutations in BRCA1/2 genes are responsible for a large proportion of hereditary breast and/or ovarian cancers. ...

The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Func…

Henderson(Beric R) Scientifica (Cairo) 2013-11-26

...BRCA1 gene predispose to a higher risk of breast/ovarian cancer. The BRCA1 tumor suppressor is a 1863 amino acid protein...

Order-disorder interface characterization reveals critical factors for disease …

Kallenbach(Jonah),Hsu(Wei-Lun),Dunker(A Keit… AMIA Jt Summits Transl Sci Pr… 2013-12-04

...BRCA1, and approximately 40% of Eukaryotic proteins are estimated to have significant disordered regions. Certain region...

Regulation of angiotensin II type 1 receptor expression in ovarian cancer: a po…

Bi(Fang-Fang),Li(Da),Cao(Chen),Li(Chun-Yan),… J Ovarian Res 2013-12-16

...BRCA1-mutated ovarian cancer cells.,BRCA1 dysfunction (BRCA1 mutation or hypermethylated BRCA1 promoter) ovarian cancer ...

Gene-gene interaction network analysis of ovarian cancer using TCGA data.

Ying(Huanchun),Lv(Jing),Ying(Tianshu),Jin(Sh… J Ovarian Res 2013-12-16

...BRCA1, TFDP1, FOXM1, CDK2, and DBF4 were identified as the transcript factors of the 7 modules.,our data provides a comp...

Comparative preclinical pharmacokinetics study of 3,3'-diindolylmethane formula…

Paltsev(Mikhail),Kiselev(Vsevolod),Muyzhnek(… EPMA J 2013-12-17

...BRCA1 gene mutations. Further preclinical and clinical trials are needed to prove this concept.

Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by trans…

Arbini(A A),Guerra(F),Greco(M),Marra(E),Gand… Oncogenesis 2013-12-16

...BRCA1 and BRCA2. Herein, we demonstrate that depletion of the mitochondrial genome (mtDNA) in breast, prostate and thyro...

Prolonged response to trabectedin in a heavily pretreated patient with metastat…

Meoni(Giulia),Cecere(Fabiana Letizia),Chaib(… Gynecol Oncol Case Rep 2013-12-27

...BRCA1 and ERCC1 gene status which could be involved in Trabectedin sensitivity.

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