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Yin(Q),Xiong(Z),Wang(X),Wei(TW),Chao(J),Ji... Phytomedicine 2026-03-00

...BRCA1/BRCA2-containing complex subunit 3 (BRCC3). Paeonol binding promotes the stability of BMP receptors and restores t...

Wang(L),Sardella(BR),Aronson(EK),Liu(Z),Li... NPJ Breast Cancer 2026-01-16

We utilized the K14-Cre Brca1f/fTp53f/f mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT in...

Metcalfe(KA),Kinney(AY),Narod(SA),Poll(A),... Hered Cancer Clin Pract 2026-01-17

...BRCA1 or BRCA2 PV between the ages of 35 and 70 years old, who had not elected for RRSO at least 12 months after receipt...

Samigatova(A),Altaeva(N),Suleimenov(Y),Sib... Sci Rep 2026-01-17

...BRCA1 and BRCA2 variants were found in 22% and 9% of cases, respectively; BRCA1 tumors were predominantly triple-negativ...

Yadav(S),Awasthi(P),Sinha(R),Hasan(S) In Silico Pharmacol None

...BRCA1/2-mutated cancers due to a synthetic lethality mechanism. This study presents an integrated in-silico drug discove...

Mansour(O),M Ali(S),Kazem(A),El Wakil(A) J Egypt Natl Canc Inst 2026-01-19

...BRCA1, p38 MAPK, and Akt (p = 0.001 for most correlations). Additionally, CaSR expression negatively correlated with men...

Liu(D),Fan(Z),Zhang(T),Li(X),Ming(C),Wu(J)... BMC Cancer 2026-01-19

...BRCA1 rs12516 and rs8176318, BRCA2 rs15869, XRCC4 rs2035990 and XRCC5 rs2440 were detected and analyzed in a CRC case-co...

Alnaggar(M),Chen(Y),Wang(C),Wang(S),Zhu(F)... J Gastrointest Cancer 2026-01-20

...BRCA1/2, PALB2) were identified. A comprehensive assessment revealed tumor progression, immunosuppression, and gut micro...

Lakes(J),Boschheidgen(M),Antoch(G),Klett(M... Eur Urol Open Sci 2026-02-00

...BRCA1/2), and PCa-affected men meeting familial/genetic criteria. Participants undergo prostate-specific antigen testing...

Pradutchon(S),Pithukpakorn(M),Poonyakanok(... Eur J Cancer Prev 2026-09-01

Germline BRCA1 and BRCA2 pathogenic and likely pathogenic variants (PVs) significantly increase the risk of breast cance...