...BRCA1 or BRCA2 deficient tumours are currently the focus of seminal clinical trials exploiting the concept of synthetic ...
...BRCA1/BRCA2-associated epithelial ovarian cancer (OC).,From the database of the Rotterdam Family Cancer Clinic, patients...
...BRCA1/2 (breast cancer, early onset) genes (BRCA-OC).,The Memorial Sloan-Kettering Cancer Center and the University of P...
...BRCA1- and FANCM-dependent manner prior to generation of DSB repair intermediates.
...BRCA1 mutation). In the example of a BRCA1-mutant patient, it is evident that local resection of a DCIS lesion or locali...
...BRCA1 or inactivation of BRCA2 decreased HR activity in cells, whereas gene restoration induced activity 8-fold. HR acti...
...BRCA1/2 carriers even if not statistical significance was reached. BRCA mutation carriers also demonstrated significant ...
...BRCA1, and BRCA2). Three other genes are involved in a large number of human cancers including breast as either tumor su...
...BRCA1 or BRCA2 and in mismatch repair (MMR) genes MLH1, MSH2, MSH6 or PMS2 are very rare.,We identified germline mutatio...
Missense substitutions of uncertain clinical significance in the BRCA1 gene are a vexing problem in genetic counseling f...
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