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[Detection for therapeutic targets specifically expressed in myeloma side popul…

Tagawa(Hiroyuki) Nihon Rinsho 2014-08-27

ATP binding membrane transporter such as multi drug resistant protein (MDR1) and breast cancer resistance protein (BCRP)...

CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to…

Matson(Daniel R),Stukenberg(P Todd) J Cell Biol 2014-09-23

The RZZ (Rod, ZW10, and Zwilch) complex and Mad1 proteins tightly associate with kinetochores to generate the spindle ch...

Cenp-meta is required for sustained spindle checkpoint.

Rubin(Thomas),Karess(Roger E),Rahmani(Zohra) Biol Open 2014-06-16

Cenp-E is a kinesin-like motor protein required for efficient end-on attachment of kinetochores to the spindle microtubu...

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated …

Qian(Xiangping),McDonald(Andrew),Zhou(Han-Ji… ACS Med Chem Lett 2014-06-05

Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer ...

Mutations in CENPE define a novel kinetochore-centromeric mechanism for microce…

Mirzaa(Ghayda M),Vitre(Benjamin),Carpenter(G… Hum Genet 2014-09-02

Defects in centrosome, centrosomal-associated and spindle-associated proteins are the most frequent cause of primary mic...

Rad51-Rad52 mediated maintenance of centromeric chromatin in Candida albicans.

Mitra(Sreyoshi),Gómez-Raja(Jonathan),Larriba… PLoS Genet 2014-11-24

Specification of the centromere location in most eukaryotes is not solely dependent on the DNA sequence. However, the no...

Application of mass spectrometry to characterize localization and efficacy of n…

Heckman(Karin L),Erlichman(Joseph),Reed(Ken)… Adv Exp Med Biol 2014-10-01

...CeNPs) in various tissues of healthy mice and in the brains of mice with a model of multiple sclerosis. Thus, ICP-MS ana...

Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kin…

Hori(Tetsuya),Shang(Wei-Hao),Toyoda(Atsushi)… Dev Cell 2014-08-19

In vertebrate cells, centromeres are specified epigenetically through the deposition of the centromere-specific histone ...

The centromere: chromatin foundation for the kinetochore machinery.

Fukagawa(Tatsuo),Earnshaw(William C) Dev Cell 2014-11-10

Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin s...

Structural insights into the role of the Chl4-Iml3 complex in kinetochore assem…

Guo(Qiong),Tao(Yuyong),Liu(Hejun),Teng(Maiku… Acta Crystallogr D Biol Cryst… 2014-07-09

Human CENP-N and CENP-L have been reported to selectively recognize the CENP-A nucleosome and to contribute to recruitin...

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