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A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen…

Natrajan(Rachael),Mackay(Alan),Lambros(Maryo… J Pathol 2012-05-22

...BRCA1 ER-positive breast cancers constitute sporadic cancers arising in the context of a BRCA1 germline mutation rather ...

Inactivation or non-reactivation: what accounts better for the silence of sex c…

Page(Jesús),de la Fuente(Roberto),Manterola(… Chromosoma 2012-09-05

...BRCA1, ATR, and γH2AX on unsynapsed chromosomes, followed by local changes on the sex chromatin, including histone modif...

Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair protei…

Warmoes(Marc),Jaspers(Janneke E),Pham(Thang … Mol Cell Proteomics 2012-10-30

...BRCA1. We identified a total of 3,545 proteins, of which 801 were significantly differentially regulated between the BRC...

CDKN2A is the main susceptibility gene in Italian pancreatic cancer families.

Ghiorzo(Paola),Fornarini(Giuseppe),Sciallero… J Med Genet 2012-06-11

...BRCA1 and BRCA2 as FPC candidate genes. Results The CDKN2A mutation rate in the 225 PC cases was 5.7%. The CDKN2A found...

Prevalence of BRCA1 and BRCA2 mutations in non-familial breast cancer patients …

Son(Byung Ho),Ahn(Sei Hyun),Kim(Sung-Won),Ka… Breast Cancer Res Treat 2012-11-06

...BRCA1/2 genes were identified in 65 (8.6%) patients among total 758 patients [BRCA1 mutation: 25 (3.3%), BRCA2 mutation:...

Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)poly…

Kulkarni(Shridhar S),Singh(Satyakam),Shah(Ja… Eur J Med Chem 2012-07-20

...Brca1-deficient cells with an IC(50) value of 49.0 μM and displayed >10-fold selectivity over wild type counterparts. Bi...

Nuclear Kaiso expression is associated with high grade and triple-negative inva…

Vermeulen(Jeroen F),van de Ven(Robert A H),E… PLoS One 2012-12-13

...BRCA1-associated breast cancer (p<0.001) and invasive breast cancer overexpressing EGFR (p = 0.019). We observed a corre...

Molecular and clinical analysis of predictive biomarkers in non-small-cell lung…

Passaro(A),Palazzo(A),Trenta(P),Mancini(M L)… Curr Med Chem 2012-12-12

...BRCA1 status. The use of antimetabolite drugs and the level of expression of their cellular targets seem to be correlate...

Mutational processes molding the genomes of 21 breast cancers.

Nik-Zainal(Serena),Alexandrov(Ludmil B),Wedg… Cell 2012-07-30

...BRCA1 or BRCA2 mutations exhibited a characteristic combination of substitution mutation signatures and a distinctive pr...

BRCA1 and BRCA2 unclassified variants and missense polymorphisms in Algerian br…

Cherbal(Farid),Salhi(Nadjet),Bakour(Rabah),A… Dis Markers 2012-09-06

...BRCA1/2 genes (33 BRCA1 and 47 BRCA2), 31 were new UVs (10 BRCA1 and 21 BRCA2), 7 were rare UVs (4 BRCA1 and 3 BRCA2) an...

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