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Structure of C-terminal tandem BRCT repeats of Rtt107 protein reveals critical …

Li(Xinxin),Liu(Kaixian),Li(Fudong),Wang(Junc… J Biol Chem 2012-06-12

...BRCA1 C-terminal) domains in Rtt107 that act as binding sites for other recruited proteins during DNA repair. Several Rt...

Characterization of BRCA1 protein targeting, dynamics, and function at the cent…

Brodie(Kirsty M),Henderson(Beric R) J Biol Chem 2012-04-24

...BRCA1 causes centrosome amplification and abnormal mitotic spindle assembly in breast cancer cells. The BRCA1-BARD1 hete...

The C-terminal proteolytic fragment of the breast cancer susceptibility type 1 …

Xu(Zhizhong),Payoe(Roshani),Fahlman(Richard … J Biol Chem 2012-04-24

The breast cancer susceptibility type 1 gene product (BRCA1) is cleaved by caspases upon the activation of apoptotic pat...

Impact of lifestyle factors on preneoplastic changes in prophylactic oophorecto…

Primas(Helga),Kroiss(Regina),Kalteis(Karin),… Eur J Cancer Prev 2012-05-07

...BRCA1 or BRCA2 mutations were included in this retrospective study. All women had undergone genetic counseling and proph...

Co-existence of breast and ovarian cancers in BRCA germ-line mutation carriers.

Dilawari(A),Cangiarella(J),Smith(J),Huang(A)… Ecancermedicalscience 2012-05-02

...BRCA1 or BRCA2 germ-line mutations have an average risk of 39% and 11% respectively of developing ovarian cancer by the ...

PTEN breast cancer susceptibility: a matter of dose.

Alimonti(A) Ecancermedicalscience 2012-09-06

...BRCA1 or p53 [6]. There is no current evidence that mutations in PTEN account for a substantial proportion of familial b...

Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and B…

Ramus(Susan J),Antoniou(Antonis C),Kuchenbae… Hum Mutat 2012-07-09

Germline mutations in BRCA1 and BRCA2 are associated with increased risks of breast and ovarian cancer. A genome-wide as...

Epigenetic modification and cancer: mark or stamp?

Foulkes(William D) Endocr Relat Cancer 2012-10-17

...BRCA1 and BRCA2 germline mutation carriers' by Bijron et al. published in the February 2012 issue of Endocrine-Related C...

UG repeats/TDP-43 interactions near 5' splice sites exert unpredictable effects…

Passoni(Monica),De Conti(Laura),Baralle(Marc… J Mol Biol 2012-05-07

...BRCA1, ETF1, and RXRG genes, TDP-43 binding to natural UG-repeated sequences can act as either an activator or a suppres...

Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent …

Nguyen(Diana),Zajac-Kaye(Maria),Rubinstein(L… Cell Cycle 2012-08-29

...BRCA1, BRCA2 and ATR pathway in p53-mutant lines. In contrast, topotecan alone induces the G1/S checkpoint pathway in p5...

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