Jiang(X),Zhou(Y),Wu(KK),Chen(Z),Xu(A),Cheng(… Diabetologia 2017-00-00

...Appl1 but were alleviated by beta cell-specific overexpression of APPL1. APPL1 preserved beta cell mass by reducing beta...

Cheng(KK),Lam(KS),Wu(D),Wang(Y),Sweeney(G),H… Proc Natl Acad Sci U S A 2012-06-05

...APPL1 expression in pancreatic β cells is markedly decreased in several mouse models of obesity and diabetes. APPL1 knoc...

Ji(Z),Hu(Z),Xu(Y) Int J Clin Exp Pathol 2015-00-00

APPL1, an intracellular adaptor protein, takes part in numerous metabolic reactions. Although APPL1 plays a key role in ...

Chen(Q),Liu(WY),Zhao(Z),Xie(Y),Han(BS) Zhonghua Zhong Liu Za Zhi 2012-11-00

...APPL1 in the breast fibroma, but the positive expression rate of Rab5a and APPL1 in the breast carcinomas were 91.9% and...

Ryu(J),Galan(AK),Xin(X),Dong(F),Abdul-Ghani(… Cell Rep 2014-05-22

...APPL1 as a critical molecule that promotes IRS1/2-IR interaction. APPL1 forms a complex with IRS1/2 under basal conditio...

Wang(C),Xin(X),Xiang(R),Ramos(FJ),Liu(M),Lee… J Biol Chem 2009-11-13

...APPL1 that forms a dimer with APPL1, can interacts with both AdipoR1 and AdipoR2 and acts as a negative regulator of adi...

Xin(X),Zhou(L),Reyes(CM),Liu(F),Dong(LQ) Am J Physiol Endocrinol Metab 2011-01-00

...APPL1, suggesting that APPL1 functions as a scaffolding protein to facilitate adiponectin-stimulated p38 MAPK activation...

Deepa(SS),Dong(LQ) Am J Physiol Endocrinol Metab 2009-01-00

...APPL1 is the first identified protein that interacts directly with adiponectin receptors. APPL1 is an adaptor protein wi...

Jiang(Y),Sachdeva(K),Goulbourne(CN),Berg(MJ)… bioRxiv 2025-05-08

...APPL1 within neurons (Thy1-APPL1 mice). Strongly supporting the important endosomal regulatory roles of APPL1 and their ...

Wu(Y),Lv(X),Wang(H),Qian(K),Ding(J),Wang(J),… J Mol Cell Biol 2021-00-18

...APPL1. Disrupting the interaction of APPL1 with Importin α1 abolishes nuclear accumulation of APPL1, which in turn decre...