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Suppression of transcription-replication conflicts by sequence-coordinated acti…

Ghosh(A),Ran(X),Zhang(F),Gao(B),Xu(Y),Phoon(… Nat Commun 2026-08-10

...EXO1. Combined loss of TRDMT1 and MLH1 causes extensive R-loop accumulation and transcription replication conflicts (TRC...

Lead-induced Hepatotoxicity in Rat Hepatocytes: a Transcriptomic Network Analys…

Li(X),Yang(B) Biol Trace Elem Res 2026-05-00

...EXO1) that functionally coalesce in five critical pathways: (i) core metabolic processes; (ii) bile secretion; (iii) che...

The INO80 chromatin remodeller facilitates DNA damage bypass via postreplicativ…

Wong(RP),Likhodeeva(M),Hopfner(KP),Ulrich(HD) EMBO J 2025-11-00

...Exo1-dependent gap expansion and gap filling via translesion synthesis or template switching. Importantly, its function ...

NPR1 modulates DNA replication in vascular endothelial cells via the transcript…

Zhang(F),Tang(H),Mao(X),Xiong(S),Wan(Y),Yuan… Genes Genomics 2025-11-00

...EXO1, MCM4, MCM6, TREX1 and CCNE2) was observed in NPR1-deficient cells. NPR1 knockdown increased γH2AX, particularly in...

Role of SIX5-mediated EXO1 overexpression in driving glioblastoma progression: …

Zhou(D),Song(Y),Chang(L) Brain Res 2025-11-01

...EXO1 within GBM tissues was identified. Functional analyses following EXO1 knockdown revealed significant suppression of...

EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex def…

Maric(M),Segura-Bayona(S),Kuthethur(R),Takak… Nat Commun 2025-09-26

...EXO1 performs multiple roles in DNA replication and DNA damage repair (DDR). However, EXO1 loss is well-tolerated, sugge...

Glabridin from Glycyrrhiza glabra L. Exhibits Anti-Triple-Negative Breast Cance…

Yuan(C),Lin(Z),Zhang(L),Tao(Q),Zheng(H),Feng… J Agric Food Chem 2025-09-24

...EXO1, and ATAD2) involved in cell cycle pathways and two key metabolites (N,N-dimethylarginine and Kuwanon K) were ident...

Key cell cycle genes in cervical cancer and their potential role in neuromuscul…

Qi(H),Liu(X),Sun(J),Dong(L) Eur J Transl Myol 2025-12-19

...EXO1-displayed significant overexpression in cervical cancer tissues with p values lower than 0.05. It is noteworthy tha...

Multi-omics identification of RNASE6 as an immune regulatory RNA-binding protei…

Gao(P),Gao(X),Zeng(X),Hua(X),He(W),Min(L),Yu… Autoimmunity 2025-12-00

...EXO1, FASTKD2, MBNL1, RNASE6, RUVBL2, TLR8, URB2) associated with melanoma metastasis. Among these, RNASE6 emerged as a ...

The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer.

Grimsley(HE),Courtemanche(K),Cox(S),McDermot… bioRxiv 2025-10-07

...EXO1-mediated degradation, as EXO1 depletion rescues the phenotype. We further demonstrate that the 9-1-1 complex is req...

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