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Circadian disruption increases sperm DNA damage through impaired CREB1-mediated…

Zhu(W),Hu(M),Zhang(Y),Lian(Y),Xu(Z),Huang(Q)… Biol Reprod 2026-01-11

...MRE11, and RAD51. Luciferase reporter and ChIP assay confirmed the transcriptional regulation of CREB1 on BRCA1 expressi...

Serotonin-licensed macrophages potentiate chemoresistance via inositol metaboli…

Li(J),Lu(J),Zheng(C),Huang(X),Li(H),Mai(Q),C… Cell Metab 2026-02-03

...MRE11 and facilitates MRE11-DNA binding and HR repair. Attenuating peripheral serotonin using fluoxetine-a selective ser...

CHAMP1 complex promotes heterochromatin assembly and reduces replication stress.

Li(F),Elbakry(A),Zhou(FY),Zhang(T),Ravindran… Proc Natl Acad Sci U S A 2026-01-06

...MRE11-mediated degradation. The complex also reduces RS at specific chromosomal sites, such as the heterochromatin-rich ...

The expanding roles of homologous recombination proteins in genome stability.

Sassi(L),Martinez Marroquin(A),Waked(S),Ardi… EMBO J 2026-02-00

...MRE11 and related nucleases, promote fork reversal, suppress replicative DNA gaps accumulation, and bind abasic sites, a...

MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resecti…

Sesay(F),Zhang(H),Kapoor-Vazirani(P),Jung(AT… J Clin Invest 2026-03-02

MRE11, a breast tumor suppressor and component of the MRE11-RAD50-NBS1 complex, plays a critical role in DNA end resecti...

CTCF/cohesin-binding sites are susceptible to replication-associated DNA damage…

Faseela(EE),Notani(D),Sabarinathan(R) iScience 2026-02-20

...MRE11, STN1, γH2AX, and RAD51-showed a high enrichment of these proteins at CBSs, compared with immediate flanking regio...

The inhibition of the MRN complex by Mirin radiosensitizes particularly HPV-neg…

Hildebrand(LS),Mehravani(BP),Khalifa(M),Schi… Cancer Cell Int 2026-02-04

...Mre11-Rad50-Nbs1 (MRN) inhibitor Mirin with ionizing radiation (IR). Our hypothesis is that the inhibition of the cancer...

CRISPR-Cas targeting in Haloferax volcanii promotes within-species gene exchang…

Choudhary(DK),Turgeman-Grott(I),Robinzon(S),… Microlife None

...Mre11-Rad50 complex, which are known to have elevated recombination activity, also exhibited higher mating success. Inde...

IFI16 senses and protects stalled replication forks.

Gamble(A),Ward(TA),Wheeler(OPG),Morris(JP),J… Mol Cell 2026-01-22

...MRE11, EXO1, and DNA2. Furthermore, IFI16 is required for the interferon-mediated rescue of fork protection in BRCA-defi...

The Contribution of Genetic Modifiers to Ovarian Cancer Risk in BRCA1 and BRCA2…

Cylwik(D),Dwornik(R),Białkowska(K) Cancers (Basel) 2026-01-23

...MRE11, RAD51, and 9p22.2. The analysis identified 11 variants affecting both BRCA1 and BRCA2 carriers, most of which inc...

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