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PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits…

Chen(L),Shultz(ZP),Sansone(M),Fang(B),Liu(X)… Mol Cancer Ther 2025-11-03

...TAF1 is broadly required for optimal cell growth and survival, but a subset of cell lines showed enhanced TAF1 dependenc...

Chemoselective Tagging of Protein Methacrylation.

Gao(M),Wan(Q),Zhou(S),Wu(P),Nie(W),Chen(S) J Am Chem Soc 2025-11-26

...TAF1, TACC1, and SETD3, providing new targets for the study of epigenetic regulation. This study provides an effective m...

Arabidopsis TAF1 is an MRE11-interacting protein required for resistance to gen…

Waterworth(Wanda M),Drury(Georgina E),Blunde… Plant J 2016-08-12

...TAF1 homologues termed TAF1 and TAF1b and mutant taf1b lines are viable and fertile. In contrast, taf1 null mutations ar...

Chromatin features, RNA polymerase II and the comparative expression of lens ge…

Sun(Jian),Rockowitz(Shira),Chauss(Daniel),Wa… Mol Vis 2016-05-31

...Taf1 (transcription factors) and Ctsd, Gabarapl1, and Park7 (autophagy regulators) have been identified with high levels...

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Hist…

Flynn(E Megan),Huang(Oscar W),Poy(Florence),… Structure 2016-07-18

...TAF1 also recognize the longer butyryl mark. In addition, the TAF1 second bromodomain is capable of binding crotonyl mar...

TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability,…

O'Rawe(Jason A),Wu(Yiyang),Dörfel(Max J),Rop… Am J Hum Genet 2016-03-22

We describe an X-linked genetic syndrome associated with mutations in TAF1 and manifesting with global developmental del...

X-exome sequencing of 405 unresolved families identifies seven novel intellectu…

Hu(H),Haas(S A),Chelly(J),Van Esch(H),Raynau… Mol Psychiatry 2016-09-16

...TAF1). We show that the CLCN4 and CNKSR2 variants impair protein functions as indicated by electrophysiological studies ...

Structure of promoter-bound TFIID and model of human pre-initiation complex ass…

Louder(Robert K),He(Yuan),López-Blanco(José … Nature 2016-04-20

...TAF1-13), which specifically interact with a variety of core promoter DNA sequences. Here we present the structure of hu...

Differential clonal evolution in oesophageal cancers in response to neo-adjuvan…

Findlay(John M),Castro-Giner(Francesc),Makin… Nat Commun 2016-08-26

...TAF1 and CCND2) that are absent from the paired pre-treatment sample. Neo-adjuvant chemotherapy can rapidly and profound...

Mechanism and Kinetics of Acetyl-Lysine Binding to Bromodomains.

Magno(A),Steiner(S),Caflisch(A) J Chem Theory Comput 2015-11-24

...TAF1(2) by the first molecular dynamics simulations of histone mark binding to an epigenetic reader protein. Multiple ev...

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