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The genetics of uveal melanoma: an emerging framework for targeted therapy.

Harbour(J William) Pigment Cell Melanoma Res 2012-08-29

...BRCA1-associated protein-1 (BAP1) appear to occur later and demarcate a molecular brink beyond which metastasis becomes ...

Cisplatin benefit is predicted by immunohistochemical analysis of DNA repair pr…

Pierceall(W E),Olaussen(K A),Rousseau(V),Bra… Ann Oncol 2012-12-26

...BRCA1, ERCC1, MSH2, p53, PARP1, and ATM) was assessed by immunohistochemistry on a large subset of patients (N = 769) fr...

Molecular insights on basal-like breast cancer.

Valentin(Mev Dominguez),da Silva(Sabrina Dan… Breast Cancer Res Treat 2012-11-19

...BRCA1 mutations) with dysfunction of the BRCA1 pathway. Despite the molecular and clinical similarities, these subtypes ...

EZH2 methyltransferase and H3K27 methylation in breast cancer.

Yoo(Kyung Hyun),Hennighausen(Lothar) Int J Biol Sci 2012-10-09

...BRCA1 functions.

Lipid metabolic pathways as lung cancer therapeutic targets: a computational st…

Yano(Kojiro) Int J Mol Med 2012-05-29

...BRCA1, that have been associated with both lung cancer and cell division. These results support the idea that inhibition...

Impact of lifestyle factors on preneoplastic changes in prophylactic oophorecto…

Primas(Helga),Kroiss(Regina),Kalteis(Karin),… Eur J Cancer Prev 2012-05-07

...BRCA1 or BRCA2 mutations were included in this retrospective study. All women had undergone genetic counseling and proph...

Factors influencing uptake and timing of risk reducing salpingo-oophorectomy in…

Manchanda(R),Burnell(M),Abdelraheim(A),Johns… BJOG 2012-10-15

...BRCA1/2 carriers and 0.22 (95% CI 0.19-0.26) for women of unknown mutation status (P < 0.0001); 0.42 (95% CI 0.36-0.47) ...

Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breas…

Kimbung(Siker),Biskup(Ewa),Johansson(Ida),Aa… Cancer Lett 2012-06-07

...BRCA1 mutant breast cancer cells to PARP1 inhibition by co-targeting the PI3K pathway. Human breast cancer cell lines wi...

When parents disclose BRCA1/2 test results: their communication and perceptions…

Bradbury(Angela R),Patrick-Miller(Linda),Egl… Cancer 2012-08-21

...BRCA1/2 positive or variant of uncertain significance result.,Many parents communicate their BRCA1/2 test results to you...

Online tool to guide decisions for BRCA1/2 mutation carriers.

Kurian(Allison W),Munoz(Diego F),Rust(Peter)… J Clin Oncol 2012-03-30

...BRCA1 or BRCA2 (BRCA1/2) mutations must choose between prophylactic surgeries and screening to manage their high risks o...

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