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Multiple biogeographical barriers identified across the monsoon tropics of nort…

Potter(Sally),Eldridge(Mark D B),Taggart(Dav… Mol Ecol 2012-08-08

...BRCA1, ω-globin and two anonymous loci) to investigate phylogeographic structuring and delineate the time-scale of diver...

Synthetic lethal targeting of DNA double-strand break repair deficient cells by…

Sultana(Rebeka),McNeill(Daniel R),Abbotts(Ra… Int J Cancer 2012-12-10

...BRCA1 deficient (MDA-MB-436), BRCA1 proficient (MCF-7), BRCA2 deficient (CAPAN-1 and HeLa SilenciX cells), BRCA2 profici...

BRCA1 haploinsufficiency: consequences for breast cancer.

Salmena(Leonardo),Narod(Steven) Womens Health (Lond) 2012-05-09

...BRCA1. They conclude that BRCA1 is a haploinsufficient tumor suppressor gene, which when lost through inheritance, incre...

Deubiquitinating enzyme BAP1 is involved in the formation and maintenance of th…

Yang(Fan),Jia(Sheng-Nan),Yu(Yan-Qin),Ye(Xian… Cell Stress Chaperones 2012-11-27

...BRCA1-associated protein-1 (BAP1) is a deubiquitinating enzyme whose function in the control of the cell cycle requires ...

Spontaneous disclosure of BRCA1/2 genetic test results to employers: a French p…

Eisinger(François),Fabre(Roxane),Lasset(Chri… Eur J Hum Genet 2012-12-26

...BRCA1/2 genetic test results to employers by unaffected carriers. In a national prospective cohort study on unaffected B...

Advances in using PARP inhibitors to treat cancer.

Kummar(Shivaani),Chen(Alice),Parchment(Ralph… BMC Med 2012-07-06

...BRCA1 or 2 genes. Results from such studies may define a new therapeutic paradigm, wherein simultaneous loss of the capa...

Activation of the BRCA1/Chk1/p53/p21(Cip1/Waf1) pathway by nitric oxide and cel…

Van de Wouwer(Marlies),Couzinié(Célia),Serra… Nitric Oxide 2012-10-01

...BRCA1/Chk1/p53 pathway mediated the upregulation of p21(Cip1/Waf1). We also demonstrated that the NO-mediated up-regulat...

Allelic transcripts dosage effect in morphologically normal ovarian cells from …

Abd-Rabbo(Diala),Abaji(Christine),Cardin(Gui… Cancer Prev Res (Phila) 2012-09-13

...BRCA1-4446C>T carriers lead to the same observation. Our data support the idea that one single hit in BRCA1 or BRCA2 is ...

A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replicatio…

Wigan(Matthew),Pinder(Alex),Giles(Nichole),P… J Invest Dermatol 2012-07-17

...BRCA1 suggests that an error-free mechanism may also contribute to repair. Loss of the UVR-induced G2-phase checkpoint r...

BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic b…

Bosviel(Rémy),Garcia(Stéphane),Lavediaux(Gui… Cancer Epidemiol 2012-09-18

...BRCA1 oncosuppressor.,BRCA1 promoter methylation rate in PBCs was 47.1% with a 95% confidence interval [46.1; 48.1] in b...

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